摘要
Abstract
Objective To evaluate the protective effects of traditional Chinese medicine injection against anthracycline-induced cardiac toxicity. Methods All 120 malignant tumor patients were randomly classified into group A, B, C, D (30 patients in each group). All the patients were treated with the chemotherapy regimens including anthracyclines. Patients in group A, B, C, and D were respectively given HuangQi injection, ShenMai injection, dexrazoxane, traditional Chinese medicine injection combined with dexrazoxane for four chemotherapy cycles based on the original chemotherapy regimens, 28 days was set a cycle. The changes of electro-cardiogram (ECG), left ventricular ejection fraction (LVEF) and qualitative detection of cardiac troponin I (cTnI) were observed before and after treatment. Results The percentage of patients with abnormal ECG in group D was sig-nificantly lower than that in group A, B, C after treatment (P=0.02, 0.04, 0.04, respectively), but there were no significant differ-ences between group A, B, C (P=0.77,0.77, 1.00, respectively). The LVEF was decreased markedly after treatment in group A, B, C (P=0.00) after treatment and there was no significant difference before and after treatment in group D (P=0.06) and it was significantly higher than that in group A, B, C (P=0.00) . No significant differences in the percentage of patients with abnormal cTnI were observed between group A, B, C, D (P=1.00, 0.55, 0.55, 0.55, 0.55, 1.00, respectively). Conclusion HuangQi and ShenMai injection had certain protective effects against the cardiac toxicity induced by anthracyclines. They had equivalent effects to dexrazoxane and it could assist dexrazoxane to against the cardiac toxicity of anthracyclines.关键词
黄芪注射液/参麦注射液/右丙亚胺/蒽环类药物/心脏毒性/保护作用Key words
ShenMai injection/HuangQi injection/Dexrazoxane/Anthracyclines/Cardiac toxicity/Protective effect分类
医药卫生
