肿瘤药学Issue(6)：426-431,6.DOI:10.3969/j.issn.2095-1264.2013.105
SIRT1基因多态性与肺癌化疗敏感性的关系
Effects of SIRT1 Genes Polymorphisms on the Chemosensitivity of Patients with Lung Cancer
摘要
Abstract
Objective To explore the relationship between the SIRT1 genetic polymorphisms and chemosensitivity to plati-num-based chemotherapy in lung cancer patients. Methods A total of 338 lung cancer patients (184 resistant and 154 sensitive) were selected and treated by platinum-based chemotherapy in this study. All single nucleotide polymorphisms in SIRT1 gene were analyzed and four tagging SNPs were final y screened for genotyped. The odds ratios (OR) with 95%confidence intervals (CI) were used to assess the effect of SIRT1 Genes Polymorphisms on the chemosensitivity of patients with lung cancer. Results We found a significant association of SIRT1 rs3758391 polymorphism with platinum-based chemotherapy effectiveness in lung cancer patients who were older than 60 years (OR=0.38, P=0.049). While no significant correlation was discovered between rs3740051, rs12778366 genetic polymorphism and platinum-based chemotherapy effect . Conclusion Our findings suggest that the SIRT1 rs3758391 genetic polymorphism can affect platinum-based chemotherapy sensitivity in lung cancer patients, and SIRT1 may be act as a potential biomarker on lung cancer chemotherapy response.关键词
SIRT1/单核苷酸多态性/肺癌/化疗敏感性Key words
SIRT1/Single nucleotide polymorphism/Lung cancer/Chemosensitivity分类
医药卫生引用本文复制引用
符一岚,王瑛,尹继业,任华益,周宏灏,刘昭前..SIRT1基因多态性与肺癌化疗敏感性的关系[J].肿瘤药学,2013,(6):426-431,6.基金项目
国家高技术发展计划重大专项（863项目）（NO:2012AA02A517），国家自然科学基金项目（NO:81173129,81373490）。 （）
