肿瘤药学Issue(6)：451-454,4.DOI:10.3969/j.issn.2095-1264.2013.110
周剂量多西他赛联合三维适形放疗治疗老年非小细胞肺癌的临床观察
Clinical Observation on the Effects of Weekly Docetaxel Combined with Three-dimensional Conformal Radiotherapy in the Treatment of Elderly Patients with Non-small Cell Lung Cancer
谭新劲 1任丽 1李迎春 1郑佳利1
作者信息
- 1. 解放军第四五二医院放疗科，四川 成都，610021
- 折叠
摘要
Abstract
Objective To investigate the clinical effects of weekly docetaxel with synchronous conformal radiotherapy on eld-erly patients with non-small cell lung cancer. Methods A total of 85 elderly patients with non-small cell lung cancer admitted in our hospital between June 2009 and December 2011 were selected and randomly divided into chemoradiotherapy group (C+R group, n=46) and radiotherapy group (R group, n=39). All patients were treated with three-dimensional conformal radiation (2~2.6 Gy per fraction, total dose of 60~70 Gy), and the patients in the chemoradiotherapy group were also given weekly 30 mg·m-2 of docetaxel intravenously for 5~6 weeks. The efficacy and adverse reactions were compared between the two groups. Results The overall response rates (CR+PR) were 84.8%and 64.1%in the chemoradiotherapy group and radiotherapy group respectively (P<0.05). The one-year overall survival rates were 82.7%and 65.1%respectively in the two groups (P>0.05), and one-year progression-free survival rates were 64.9%and 40.6%respectively (P<0.05). The incidence of hematological toxic-ity was higher in the chemoradiotherapy group than in the radiotherapy group, but all therapy plans were successfully completed. Conclusions Compared with radiotherapy alone, weekly docetaxel combined with three-dimensional conformal radiotherapy could improve the short-term efficacy on elderly patients with non-small cell lung cancer, and the side effects were tolerated.关键词
多西他赛/三维适形放疗/非小细胞肺癌/临床疗效Key words
Docetaxel/Three-dimensional conformal radiotherapy/Non-small cell lung cancer/Clinical efficacy分类
医药卫生引用本文复制引用
谭新劲,任丽,李迎春,郑佳利..周剂量多西他赛联合三维适形放疗治疗老年非小细胞肺癌的临床观察[J].肿瘤药学,2013,(6):451-454,4.
