肿瘤药学Issue(2)：135-138,4.DOI:10.3969/j.issn.2095-1264.2014.027
多西紫杉醇对鼻咽癌放疗增敏作用的临床观察
Clinical Observation on the Sensitization Effects of Docetaxel on the Radiotherapy of Nasopharyngeal Carcinoma
温本 1杨志华 1颜劲 1郑文滔1
作者信息
- 1. 湛江中心人民医院，广东 湛江，524037
- 折叠
摘要
Abstract
Objective To study the sensitization effect and safety of Docetaxel on the radiotherapy of nasopharyngeal carci-noma. Methods Sixty cases of nasopharyngeal carcinoma patients confirmed by pathological diagnosis were randomly divided into the experimental group and control group, 30 cases in each group. The control group adopted single radiotherapy, while the experimental group was added with static drops of docetaxel 40 mg, 1 time per week. The therapeutic effect and adverse reac-tions were observed and compared between two groups after 1-month treatment. Results The total effective rate of experimental group and control group were respectively 83.33%and 53.33%, with statistically significant difference (P<0.05).There were no significant differences in the incidence rate of adverse reactions such as leukopenia, pharyngalgia, cutaneous reaction, nausea and vomitting between two groups (P>0.05). Conclusion Docetaxel combined with radiotherapy was more effective than single radiotherapy in the treatment of nasopharyngeal carcinoma, and would not increase the adverse reactions. It was worthy of clini-cal application as well as further study.关键词
鼻咽癌/多西紫杉醇/放疗增敏Key words
Nasopharyngeal carcinoma/Docetaxel/Radiosensitizer分类
医药卫生引用本文复制引用
温本,杨志华,颜劲,郑文滔..多西紫杉醇对鼻咽癌放疗增敏作用的临床观察[J].肿瘤药学,2014,(2):135-138,4.
