摘要
Abstract
Objective:To investigate the effect and mechanism of Ulinastatin on myocardial ischemia-reperfusion injury in acute myocardial infarction and cardiopulmonary resuscitation (CPR).Method:A retrospective analysis of 63 cases of acute myocardial infarction in critically ill patients after CPR,according to whether using Ulinastatin,who were divided into conventional group (not used combination Ulinastatin group) and observed group (used Ulinastatin group).Heart rate (HR),mean arterial blood pressure (MBP),creatine kinase (CK-MB) and the rate of ventilator-associated pneumonia (VAP),were observed. Serum IL-6, TNF-α,MMP-9 levels were simultaneous detected of two groups and compared.Result:The mortality,VAP rates of observed group were 13.8%,6.9%,which were significantly lower than the conventional group 38.2%,32.4%,the difference was significant(P<0.05).The improvements of MBP,HR,CK-MB in observed group were significantly superior to the conventional group(P<0.05).The IL-6,TNF-α,MMP-9 of the two groups in the first day after CPR was no significantly different (P>0.05).After CPR five days,IL-6,TNF-α,MMP-9 increased compared with the first day,but the conventional group were significantly higher than the observed group(P<0.05).Conclusion:Ulinastatin can significantly reduce myocardial ischemia-reperfusion injury in AMI patients,reduce mortality and improve clinical outcomes,which may be related to inhibit inflammatory cytokine production and reduce inflammation injury.关键词
乌司他丁/心肌缺血/再灌注/炎症因子Key words
Ulinastatin/Myocardial ischemia/Reperfusion/Inflammatory cytokines分类
医药卫生
