摘要
Abstract
Objective:To observe the efficacy of different maintenance doses of dexmedetomidine for sedation in gynecology surgery.Method:60 patients which were scheduled for gynecology surgery with combined spinal-epidural anesthesia(CSEA) were randomly divided into two groups,30 cases in each group.After the anesthesia,both groups were given loading dosage of 0.9μg/kg of dexmedetomidine by continuous pump-infusion for 10 minutes,then maintained with it by intravenous pumping at the rate of 0.4μg/(kg·h)(Group A)or 0.5μg/(kg·h)(Group B).Both groups were injected dezocine 0.1 mg/kg before the skin was cut.HR, MAP,SpO2 were recorded at 5 minutes after entering the operating room(base value)(T0),after CSEA(T1),after infusing the loading dose of dexmedetomidine (T2),half an hour after the operation(T3),and after operation(T4).The traction reaction during operation and the Ramsay scores at T2,T3 were also observed. Result:Compared with T0,there were no significant differences about MAP and SpO2 at T1,T2,T3,T4 in both groups(P>0.05).HR at T2,T3 of both groups were obviously lower than those at T0(P<0.05),but compared with T2,there were no significant differences about HR at T3 in both groups(P>0.05).There were no significant differences about MAP,SpO2 and HR at T0,T1,T2,T3,T4 between the two groups(P>0.05).8 patients achieved 1 score in group A about Ramsay, of which 6 cases were restless because of the traction reaction.All patients achieved 2-4 scores in group B about Ramsay,of which only 2 cases complained for stomach discomfort(P<0.05).Conclusion:Dexmedetomidine intravenous infusion 0.9μg/kg followed by 0.5μg/(kg·h) can effectively reduce the traction reaction and provide safer and more effective depth of sedation during gynecology.关键词
右美托咪定/妇科手术/镇静Key words
Dexmedetomidine/Gynecology Surgery/Sedation分类
医药卫生
