摘要
Abstract
Objective:To investigate distribution characteristics and antibiotic resistance of pathogens in septicemia of the newborn,and to guide the clinical treatment.Method:The clinical data of 177 neonates who were received in the neonatology ward or the neonate intensive care unit (NICU) and diagnosed with septicemia from January 2010 to April 2013 were collected,and the results of blood culture and antimicrobial susceptibility were reviewed retrospectively. Result:A total of 184 strains were detected from 177 blood specimens(7 patients were isolated two kinds of pathogens in one specimen),of which 110(59.8%) strains were Gram-positive bacteria,and 56(30.4%) strains were Gram-negative bacteria,and 18(9.8%) strains were fungi.Gram-positive bacteria were mainly consisted of Staphylococcus epidermidis(23.9%),Staphylococcus haemolyticus(8.2%) and staphylococcus haemolyticus(6.5%),while the Coagulase-negative Staphylococcus accounted for 46.7%of the total separated strains.Klebsiella pneumoniae and Escherichia coli were the dominant strains in the Gram-negative bacterias,accounted for 12.0%and 10.3%of the total isolated strains respectively.Candida albicans was the major strain of fungi,amounted to 6%of total detected strains. Gram-positive bacteria demonstrated a strong resistance to Penicillin G,ampicillin,macrolides and lincomycin,while they was sensitive to Piperacillin/tazobactam,quinolones,and Vancomycin-resistant strain was not found.The Gram-negative bacteria were resistant to Ampicillin and cephalosporins,but their susceptibility to Amikacin ,quinolones and carbapenems was obvious.Fungi had a high sensitivity to Itraconazole antibiotics.Conclusion:Coagulase-negative staphylococci is the most common pathogens causing neonatal sepsis in the latest three years in our hospital,followed by Klebsiella pneumoniae and Escherichia coli.They have resistance to common antibiotics.Candida albicans is the main pathogen of Fungal sepsis,has a high sensitivity to Itraconazole antibiotics.It is suggested that antibiotics should be used under the guidance of antibiotic susceptibility testing.关键词
新生儿/败血症/病原菌/耐药性Key words
Neonate/Septicemia/Pathogen/Antibiotic resistance分类
医药卫生
