组织工程与重建外科杂志Issue(5)：292-294,3.DOI:10.3969/j.issn.1673-0364.2013.05.015
巨噬细胞参与骨骼肌再生机制的研究进展
Research Progress in Mechanisms of Macrophages Participating in Skeletal Muscle Regeneration
乔娟 1郝晓艳 2郭树忠2
作者信息
- 1. 100091 北京市 解放军第309医院
- 2. 710032陕西省西安市 第四军医大学西京医院
- 折叠
摘要
Abstract
In recent years, many researches have demonstrated that macrophages play a vital role in organ or tissue regeneration. Macrophages are necessary for skeletal muscle regeneration after injury. The recruitment of circulating mono-cytes/macrophages was mediated through myogenic cells and muscle resident macrophages. Macrophages are involved in both phases of skeletal muscle regeneration: first, swallowing necrotic myo-fibers, then the phenotype of macrophages switched from pro-inflammatory to anti-inflammatory. Second, factors secreted by anti-inflammatory macrophages improved the differentiation of myogenic cells and resulted in regeneration of skeletal muscle.关键词
巨噬细胞/骨骼肌再生/成肌细胞/巨噬细胞活化/组织修复Key words
Macrophages/Skeletal muscle regeneration/Myogenic cells/Macrophage activation/Tissue repair分类
生物科学引用本文复制引用
乔娟,郝晓艳,郭树忠..巨噬细胞参与骨骼肌再生机制的研究进展[J].组织工程与重建外科杂志,2013,(5):292-294,3.
