诊断学理论与实践2014，Vol.13Issue(2)：182-186,5.DOI:10.3969/j.issn.1671-2870.2014.02.015
神经轴突导向分子Sema3A在卵巢癌中的表达及其临床意义
Expression of Sema3A in ovarian cancer and its clinical significance
徐云钊 1韩娟娟 1奚庆华 1叶青1
作者信息
- 1. 南通大学附属医院妇产科，江苏 南通 226001
- 折叠
摘要
Abstract
Object: To investigate the expression of Sema3A in human epithelial ovarian tumor and the correlation of Sema3A expression with clinicopathological features. Methods:Expressions of Sema3A in 80 paraffin embedded ovarian tumor samples and 8 fresh ovarian tumor specimens were determined by immunohistochemical staining and Western blotting, respectively. The data were analyzed with SPSS 19.0 software package for χ2 test. Results: Immunohistochemical findings revealed that the expression of Sema3A differed in ovarian cancer, transitional cell ovarian tumor and benign ovarian tumor. Sema3A expression was correlated significantly with pathologic stage (Spearman′s r=-0.624, P<0.001) and histologic subtype (Spearman′s r=0.311, P<0.05) of ovarian cancer. Western blotting results of 8 fresh specimens demonstrated similar results. The expression of Sema3A differed significantly between benign ovarian tumor and ovarian cancer (P<0.001). Conclusions: Expression level of Sema3A decreases gradually from ovarian cancer, transitional cell ovarian tumor to benign ovarian tumor. Sema3A expression increase with the increase in malignancy degree. Expression of Sema3A has certain value for the diagnosis and malignancy degree estimation of ovarian cancer.关键词
卵巢癌/Sema3A/诊断Key words
Ovarian cancer/Sema3A/Diagnosis分类
医药卫生引用本文复制引用
徐云钊,韩娟娟,奚庆华,叶青..神经轴突导向分子Sema3A在卵巢癌中的表达及其临床意义[J].诊断学理论与实践,2014,13(2):182-186,5.
