摘要
Abstract
Objective To investigate the age of onset,location,clinical feature,diagnosis,immunohistochemical characteristic and treatment status of gastrointestinal stromal tumor.Methods Retrospectively analyzed the position,clinical feature,methods of diagnosis and treatment,pathological and immunohistochemical characteristics of 90 cases of gastrointestinal stromal tumor who were confirmed by pathological and immunohistochemical examination in our hospital nearly 9 years.Results Gastrointestinal stromal tumor incidence ratio was 1.5:1 for men and women.The range of age was 21-86 years old,most of patients over 60 years old.Gastrointestinal stromal tumor mainly originated in stomach (55.6％) or small intestine (27.8％).Clinical manifestations lacked specificity,and initial symptoms mainly were haematemesis,melena or hematochezia,abdominal pain and abdominal distension.Clinical diagnosis of stromal tumor was difficult,correct diagnosis depended on histopathological and immunohistochemical examination of surgery or biopsy specimens.The positive rate of immunohistochemistry detecting CD117 was 94.05％ (79/84),that of CD34 was 92.86％ (78/84),and that of CD117 combined with CD34 was 92.86％ (78/84).Complete resection of lesion with operation is the only effective treatment method of gastrointestinal stromal tumor.Gleevec had a certain role for inoperable patients or in preventing recurrence.Conclusions Gastrointestinal stromal tumor is an undecided pluripotent mesenchymal tumor lacking of specific clinical manifestations.The diagnosis must depend on gross specimens or immunohistochemical pathology results.CD117 and CD34 have an important value in the diagnosis.Surgery resection is the only effective treatment method.关键词
胃肠道间质瘤/病理/免疫组化/外科手术Key words
Gastrointestinal stromal tumor/ Pathology/ Immunohistochemistry/ Surgery
