摘要
Abstract
Objective To explore the role of continuously monitoring serum procalcitonin level in severe stroke.Methods 86 patients with severe stroke confirmed by microbiological examination were randomly selected and were divided into an infected groups (n=48) and a non-infected group (n=38) in terms of whether was bacterially infected.All patients were tested PCT and C-reactive protein (CRP) levels by fasted venous blood.Results Day 1,4,and 7,the PCT levels were (1.34 ± 0.48) ng/ml,(3.61 ± 1.40) ng/ml,(2.12 ± 1.13) ng/ml and the CRP levels were (12.76 ± 5.12) mg/L,(18.68 ± 8.12) mg/L,and (13.27 ± 5.19) mg/L in the infection group respectively,which were significantly higher than those in the non-infected group (PCT levels:[0.27 ± 0.13] ng/ml,[0.37 ± 0.07] ng/ml,[0.19 ± 0.13] ng/ml; CRP levels:[6.59 ± 4.62] mg/L,[8.61 ± 4.30] mg/L,[5.46 ± 4.13] mg/L),with statistical differences (P ＜ 0.05).With PCT ＜ 0.5 ng/ ml as the standard negative bacterial infection,the PCT diagnostic sensitivity was 81.3％ on day 1,91.7％ day 4,and 87.5％ day 7.With CRP ＜ 10.0 mg/L as the standard negative bacterial infection,the sensitivities were 64.6％,85.4％,and 75.0％ on day 1,4,and 7,respectively.The diagnostic specificities of PCT and CRP were 94.7％ and 71.1％ on day 1,with statistical difference (P ＜ 0.05),89.5％ and 81.6％ day 4,and 86.8％ and 76.3％ day 7,respectively.Conclusions Continuously monitoring serum procalcitonin level can find out bacterial infections easily and guide antibiotic usage.关键词
卒中/PCT/CRP/监测Key words
Stroke/ PCT/ CRP/ Monitoring
