江苏大学学报（医学版）2014，Vol.24Issue(3)：240-244,5.DOI:10.13312/j.issn.1671-7783.y140059
短期胰岛素泵强化治疗对初诊2型糖尿病患者血清超敏C反应蛋白的影响
Effect of short-term continuous subcutaneous insulin infusion treatment on newly diagnosed type 2 diabetes related to serum high-sensitive C-reactive protein
摘要
Abstract
Objective:To investigate thc changcs of short-term continuous subcutaneous insulin infusion (CSⅡ) on serum hs-CRP levels in patients with newly-diagnosed type 2 diabetes mellitus,and to identify the influencing factors for changes of hs-CRP.Methods:A total of 70 normal controls,120 patients with newly diagnosed type 2 diabetes mellitus were treated with CSⅡ for 2 weeks.Oral glucose tolerance test and insulin releasing test were performed before and after intensive insulin therapy; meanwhile,blood lipid,hsCRP and other parameters were measured.Results:①Serum hs-CRP was significantly higher [2.76 (0.81 ～ 6.33) mg/L] in newly diagnosed type 2 diabetes mellitus than normal controls [0.48 (0.18 ～ 0.98) mg/L].② In the T2DM group,there was a significant decrease in fasting plasma glucose (FPG),2 h plasma glucose (2hPG),HOMA-IR and hs-CRP (P ＜ 0.01 or P ＜ 0.05),a significant increase in homeostasis model assessment for insulin function.③The changes of serum CRP was positively correlated with △ SBP,△FPG,△FINS,△TC,△LDL-C,△HOMA-β,△HOMA-IR (r =0.287,0.324,0.236,0.257,0.366,0.201,0.230,P ＜ 0.05).The multiple regression analysis showed that △FPG(β =0.214,P ＜ 0.05),△FINS(β =0.376,P ＜ 0.01),△LDL-C (β =0.263,P ＜ 0.05),△HOMA-β (β =0.352,P ＜ 0.01),△HOMA-IR(β =0.279,P ＜ 0.05)were independent related factors in the influence of the changes of hsCRP levels.Conclusion:In type 2 diabetic patients,elevated serum hs-CRP levels were significantly decreased after CSⅡ treatment.The multiple regression analysis showed that △FPG,△LDL-C,△FINS,△HOMA-β and △HOMA-IR were independent related factors in the influence of the changes of hs-CRP levels.关键词
2型糖尿病/胰岛素泵/超敏C反应蛋白Key words
type 2 diabetes mellitus/ continuous subcutaneous insulin infusion/ high-sensitive C-reactive protein分类
医药卫生引用本文复制引用
汤冰倩,胡浩,钱唯韵,朱天一,俞淑琴,孙文君,杨玲,王东,王济芳..短期胰岛素泵强化治疗对初诊2型糖尿病患者血清超敏C反应蛋白的影响[J].江苏大学学报（医学版）,2014,24(3):240-244,5.基金项目
国家自然科学基金资助项目(81370965) （81370965）
江苏省自然科学基金资助项目(BK2009208) （BK2009208）
江苏省卫生厅国际交流支撑计划及面上科技项目(H201247) （H201247）
镇江市社会发展基金项目(SH2012027) （SH2012027）
