江苏大学学报（医学版）2014，Vol.24Issue(3)：260-263,266,5.DOI:10.13312/j.issn.1671-7783.y140007
长链非编码RNA HOTAIR在食管鳞癌中的表达及意义
Expression and clinical significance of long non-coding RNA HOTAIR in patients with esophageal squamous cell carcinoma
摘要
Abstract
Objective:To explore the expression and clinical significance of long non-coding RNA HOTAIR (lncRNA HOTAIR) in esophageal squamous cell carcinoma (ESCC) and analyze its correlation with transforming growth factor β1 (TGF-β1).Methods:Quantitative real-time polymerase chain reaction was used to detect the expressions of HOTAIR mRNA and TGF-β1 mRNA in 57 ESCC tissues and matched tumor-free tissues.The relationship between HOTAIR mRNA and clinico-pathological features of ESCC was also analyzed.Results:In comparison to matched tumor-free tissues,the expressions of HOTAIR mRNA (Z=-2.507,P =0.012) and TGF-β1 mRNA (Z =-2.038,P =0.042) were found to be elevated and lowered,respectively,in ESCC tissues.Up-regulation of HOTAIR expression was correlated with tumor differentiation degree and clinical stage.The expression of HOTAIR was negative correlated with TGF-β1 (r =-0.406,P =0.002).Conclusion:lncRNA HOTAIR in ESCC tissues may play a significant role in the occurrence and development of ESCC through TGF-β1 signaling pathways.关键词
HOTAIR/转化生长因子β1/食管鳞癌Key words
HOTAIR/ transforming growth factor β1/ esophageal squamous cell carcinoma分类
医药卫生引用本文复制引用
张曌玥,尹越,牟笑,吴诗,毛朝明,陈德玉..长链非编码RNA HOTAIR在食管鳞癌中的表达及意义[J].江苏大学学报（医学版）,2014,24(3):260-263,266,5.基金项目
镇江市社会发展支撑计划项目(SH2011019 （）
SH2012023) （）
