乌司他丁减轻失血性休克神经元线粒体功能障碍的临床观察OA
Clinical observation on protective effect of Ulinastatin against hemorrhagic shock-induced neuron mitochondrial dysfunction
目的 探讨乌司他丁对失血性休克诱导的神经元线粒体功能障碍的影响.方法 18只大鼠随机分为对照组、休克+生理盐水组和休克+乌司他丁组,在失血性休克造模后相应予以生理盐水或乌司他丁治疗.透射电镜检测神经元线粒体超微结构;JC-1探针流式细胞仪探测线粒体膜电位(△ψm)变化;荧光素-荧光素酶试剂盒测定ATP含量;过氧化脂质(lipid hydroperoxide,LPO)试剂盒检测血清LPO含量.结果 与对照组比较,生理盐水组神经元线粒体肿胀、嵴结构模…查看全部>>
Objective To investigate protective effect of Ulinastatin on hemorrhagic shock-induced neuron mitochondrial dysfunction.Methods 18 rats were randomly divided into control group,shock+normal saline (NS) group and shock+Ulinastatin group.Rats were received homologous NS or Ulinastatin treatment after hemorrhagic shock induction.Ultrastructure of neuron mitochondria was detected by electron microscope; change of mitochondrial membrane potential (△ ψm) by …查看全部>>
林博;高友光;林财珠
350004 福州,福建医科大学附属第一医院麻醉科350004 福州,福建医科大学附属第一医院麻醉科350004 福州,福建医科大学附属第一医院麻醉科
失血性休克乌司他丁线粒体
Hemorrhagic shockUlinastatinMitochondria
《国际医药卫生导报》 2014 (11)
1536-1539,4
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