国际医药卫生导报2014，Vol.20Issue(12)：1666-1668,3.DOI:10.3760/cma.j.issn.1007-1245.2014.12.004
局部亚低温延长急性脑梗死治疗时间窗的临床研究
Local mild hypothermia for extending therapeutic time window of acute cerebral infarction
摘要
Abstract
Objective To investigate the clinical effect of local mild hypothermia for extending the therapeutic time window of acute cerebral infarction.Methods 77 patients with acute cerebral infarction admitted into our hospital from April 2013 to February 2014 were chosen as study objects and were divided into group A(≤ 6 h),group B (6 ～ 12 h),group C (12 ～ 24 h),and group D (≥ 24 h) according to when the treatment started,then all received local mild hypothermia treatment.The serum level of nitrogen monoxidum (No),the score of NIHSS and superoxide dismutase (SOD) of the four groups when admitted and day 7,14,and 30 of the treatment were compared.Results The NIHSS score had no statistical difference (P ＞ 0.05) between the four groups when admitted and markedly decreased in the four groups day 7,14,and 30,with statistical differences between different time periods (P ＜ 0.05).The serum level of NO and serum SOD activity had no statistical differences (P ＞ 0.05) between the four groups when admitted and the serum level of NO markedly decreased and the serum SOD activity markedly increased in the four groups day 7 and 14,with statistical differences between different time periods (P ＜ 0.05).Conclusions The best therapeutic time window of local mild hypothermia for patients with acute cerebral infarction is within 6 hours of onset; the treatment effect of 6 to 24 hour period decreases with time; and over 24 hours the effect is not obvious.关键词
急性脑梗死/局部压低温/治疗时间窗Key words
Acute cerebral infarction/Local mild hypothermia/Therapeutic time window引用本文复制引用
廖品君,高彬..局部亚低温延长急性脑梗死治疗时间窗的临床研究[J].国际医药卫生导报,2014,20(12):1666-1668,3.基金项目
惠州市科技局(20130801) （20130801）
