国际医药卫生导报2014，Vol.20Issue(16)：2436-2439,4.DOI:10.3760/cma.j.issn.1007-1245.2014.16.008
HPV E6/E7 mRNA检测在ASC-US患者分层处理中的应用研究
Application of HPV E6/E7 mRNA test in hierarchical processing of ASC-US
摘要
Abstract
Objective To investigate the application of human papilloma virus (HPV) E6/E7 mRNA test to process atypical squamous cells of undetermined significance (ASC-US) in layers.Methods 312 patients with ASC-US underwent HPV E6/E7 mRNA test.The pathology data was statistically analyzed.Results Stratified by pathology,the positive rate of HPV E6/E7 mRNA was 43.40％ in 211 patients (67.63％) with inflammation or normal,71.21％ in 66 patients (21.15％) with LSIL (low-grade squamous intraepithelial lesion) and 91.18％ in 35 patients (11.22％) with HSIL (high-grade squamous intraepithelial lesion).Among the detection efficiency of HPV E6/E7 mRNA test for ISIL/HSIL,the sensitivity was 78.22％,the specificity was 56.40％,positive predictive value (PPV) was 46.20％,and negative predictive value (NPV) was 84.40％.Conclusion HPV E6/E7 mRNA test can be well used in hierarchical processing of ASC-US to avoid the misdiagnosis of high-grade cervical lesion.关键词
人乳头状瘤病毒/E6/E7/ASC-US/鳞状上皮内病变Key words
Human papilloma virus/ E6/E7/ Atypical squamous cells of undetermined significance/ Squamous intraepithelial lesion引用本文复制引用
吴志东..HPV E6/E7 mRNA检测在ASC-US患者分层处理中的应用研究[J].国际医药卫生导报,2014,20(16):2436-2439,4.基金项目
广州开发区科技计划项目(2010Q-P186) （2010Q-P186）
