Abstract
Objective:To investigate the effect of long-term oral administration of fudosteine and N-acetylcysteine on chronic obstructive pulmonary disease (COPD) complicated with pulmonary fibrosis.Methods:Each 60 patients with COPD,COPD complicated with pulmonary fibrosis patients and healthy subjects were selected as the COPD-group,the complicated-group and the control-group,respectively.The eight indicators,which were interleukin-1,interleukin-8,laminin,hyaluronic acid,FVC percent predicted (FVC％ pred),the first one second forced expiratory volume percent predicted (FEV1 ％ pred),first second vital capacity,forced expiratory volume occupancy percentage (FEV1/FVC),and carbon monoxide diffusing capacity percent predicted (DLCO％pred) in the three groups were detected.The St George's Respiratory Questionnaire (SGRQ) and high-frequency CT (HRCT) in COPD-group and complicated-group were surveyed and examed.Then the COPD-group and complicated-group were equally randomized into 3 groups respectively,non-intervention-COPD group,fudosteine-COPD-group,N-acetylcysteine-COPD-group,nonintervention-complicated-group,fudosteine-complicated group,N-acetylcysteine-complicated group.Fudosteine group and N-acetylcysteine group were recepted oral adminstration of fudosteine 0.4 g and N-acetylcysteine 0.6 g,respectively,3 times per day,for six months.The non-intervention-group,fudosteinegroup and N-acetylcysteine-group were retested these indicators and examination.Results:Compared with the control group,COPD group and complicated group showed higher levels of interleukin-1,interleukin-8,laminin,hyaluronic acid (P ＜ 0.05),which in the complicated group were significantly higher than the COPD group (P ＜ 0.05) ; while with lower levels of FEV1 ％ pred,FVC％ pred,FEV1/FVC,DLCO％ pred (P ＜ 0.01),which in the fudosteine group were significantly lower than the COPD group (P ＜ 0.05).Compared with non-interventione group,fudosteine group and N-acetylcysteine group showed higher levels of interleukin-1,interleukin-8,laminin and hyaluronic acid,higher levels of FEV1 ％ pred,FVC％ pred,DLCO％ pred; meanwhile,quality of life was improved significantly,imaging performed significantly better under HRCT.The changes in fudosteine group were more obvious than in N-acetylcysteine group (P ＜ 0.05).Conclusion:Long-term oral administration of fudosteine and N-acetylcysteine could delay the progress of COPD,and improve COPD patients with pulmonary fibrosis.The therapeutic effect of fudosteine was stronger than N-acetylcysteine.关键词
慢性阻塞性肺疾病/肺纤维化/福多司坦/乙酰半胱氨酸Key words
chronic obstructive pulmonary disease/ pulmonary fibrosis/ fudosteine/ N-acetylcysteine分类
医药卫生
