摘要
Abstract
Objective To investigate the effect of continuous blood purification therapy in treatment of severe acute pancreatitis (SAP).Methods 23 patients were treated with traditional clinical medicine,23patients were treated on the basis of the former,with continuous blood purification (CBP) technology added,the inflammatory factors and other indicators of the situation in both groups were compared,Results There was significant difference of IL-1,IL-6,IL-8 and TNF-α treatment of two groups of patients in the time of 24h and 48h after treatment (P ＜ 0.05),observed indexes were significantly lower than those of the control group [IL-1,IL-6,IL-8,TNF-α were (246.52 ± 31.84) pg/ml,(15.12 ± 1.07) pg/ml,(16.05 ± 1.08) pg/ml and (1.42 ± 0.31) ng/L 24 h after treatment (190.46 ± 27.65) pg/ml,(11.07 ± 1.87) pg/ml,(11.04 ± 1.57) pg/ml and (0.68 ± 0.34) ng/L 48 h after treatment respectively].There was significant difference of Ang-Ⅰ,Ang-Ⅱ,E,aldosterone in the treatment of the two groups patients in the time of 24 h and 48 h after treatment (P ＜ 0.05) [Ang-Ⅰ,Ang-Ⅱ,E,ALD were (1.34 ± 1.17) ng/L,(0.72 ± 5.37) ng/L,(1.05 ± 0.21) ng/ml and (145.27 ± 15.34)pg/ml 24 h later,(9.28 ± 1.16) ng/L,(48.42 ± 4.10) ng/L,(0.63 ± 0.11) ng/ml and (99.31 ± 11,16) pg/ml 48 h later].Conclusion CBP can obviously alleviate the severity of SAP,and promote the inflammatory factors and improve the renin-angiotensin-aldosterone system.关键词
持续性血液净化/重症急性胰腺炎/RAAS/炎性因子Key words
Continuous blood purification/ Severe acute pancreatitis/ RAAS/ Inflammatory factor
