国际医药卫生导报2014，Vol.20Issue(18)：2867-2871,5.DOI:10.3760/cma.j.issn.1007-1245.2014.18.032
16种中药颗粒剂对5种耐药菌株的体外抑菌效果比较
In vitro antibacterial effect of 16 kinds of Chinese medicine granules on 5 kinds of drug resistant strains
李蔼文 1沈素晶 1周兵1
作者信息
- 1. 510095广州,广东省第二中医院检验科
- 折叠
摘要
Abstract
Objective To explore the in vitro antibacterial effect of scutellaria baicalensis etc.16 kinds of Chinese herbal medicine granules on methicillin-resistant staphylococcus aureus (MRSA) etc.5 common clinical drug resistant bacteria.Methods Basing on the research on traditional Chinese medicine source,16 kinds of traditional Chinese herbal medicine granules with anti-inflammatory and antibacterial effects were chosen.K-B disc agar diffusion method was used to measure the size of inhibition ring of 5 kinds clinical common resistant bacteria.Meanwhile,a broad-spectrum antibiotic was selected as a positive control.t test was used to compare with the granule.Results Baicalin had best antibacterial effect; methicillin resistant Staphylococcus aureus was highly sensitive to it but lowly sensitive to the other 4 kinds; the diameter of inhibition zone was 6-19 mm.Forsythia and mint came behind it in inhibitory effect.Isatis root,honeysuckle,chrysanthemum,Tuckahoe,Folium Isatidis,Herba Violae,and Anemarrhena granules had no inhibitory effect on the five kinds of drug resistant bacteria.For methicillin-resistant Staphylococcus aureus (MRSA),Scutellaria baicalensis didn' t statistically differed from vancomycin (P ＞ 0.05),while the rest of the granuleswere worse than vancomycin (P ＜ 0.05).For resistant Pseudomonas aeruginosa,Fructus Forsythiae didn' t statistically differed from imipenem (P ＞ 0.05),while the rest of the granules were worse than imipenem (P ＜ 0.05).For the remaining 3 resistant bacilli,granules were worse than imipenem (P ＜ 0.05).Conclusion Part of the traditional Chinese medicine granules have inhibitory effect on the 5 clinical common resistant bacteria.关键词
颗粒剂/K-B纸片琼脂扩散法/耐药菌株Key words
Granule/K-B disc agar diffusion method/Resistant strains引用本文复制引用
李蔼文,沈素晶,周兵..16种中药颗粒剂对5种耐药菌株的体外抑菌效果比较[J].国际医药卫生导报,2014,20(18):2867-2871,5.
