中国药房2014，Vol.25Issue(35)：3269-3272,4.DOI:10.6039/j.issn.1001-0408.2014.35.02
接骨木总苷片促进骨折愈合与抗炎作用研究Ⅰ
Study on Effects of Sambucus williamsii Total Glycosides Tablets on Fracture Healing and Inflammation: Part Ⅰ
摘要
Abstract
OBJECTIVE:To study the effects of Sambucus williamsii total glycosides tablets on fracture healing and inflammation.METHODS:Rabbit fracture model was induced.50 New Zealand white rabbits were randomly divided into normal control group (constant volume of normal saline),model group (constant volume of normal saline),Dieda pills group (0.28 g/kg),S.williamsii total glycosides tablets high-dose,medium-dose and low-dose groups(0.22,0.11,0.06 g/kg).They were given medicine via feedingstuff for consecutive 36 d.The bone mineral density (BMD),bone mineral content (BMC) and callus area (Area) were determined by dual energy X-ray absorptioumetry (DXA).The degree of fracture healing was observed by X-ray film.Anti-inflammatory effects were observed by mice ear swelling and rat foot swelling experiments; analgesic action was observed by hot plate method.RESULTS:High-dose,medium-dose and low-dose of S.williamsii total glycosides tablets could increase BMD and BMC in model group; the fracture site of model rabbit disappeared nearly,and periosteal reaction density increased and deepened.Medium-dose of S.williamsii total glycosides tablets could increase Area in model group.High-dose,medium-dose and low-dose of S.williamsii total glycosides tablets relieved mice ear swelling of model mice and foot swelling of model rats,and increased 1h pain threshold of normal mice.CONCLUSIONS:S.williamsii total glycosides tablets have good resistance to acute inflammation and analgesic effect and can promote the fracture healing.关键词
接骨木总苷片/骨折愈合/抗炎/镇痛Key words
Sambucus williamsii total glycosides tablets/ Fracture healing/ Anti-inflammatory/ Analgesia分类
医药卫生引用本文复制引用
杨炳友,何娅雯,朱晓清,韩华,杨柳,王秋红,匡海学..接骨木总苷片促进骨折愈合与抗炎作用研究Ⅰ[J].中国药房,2014,25(35):3269-3272,4.基金项目
国家自然科学基金面上项目(No.81173501) （No.81173501）
黑龙江中医药大学“优秀创新人才支持计划”项目(No.B201201) （No.B201201）
黑龙江中医药大学博士创新基金资助项目(No.B201003) （No.B201003）
