江苏大学学报（医学版）2014，Vol.24Issue(5)：416-419,4.DOI:10.13312/j.issn.1671-7783.y140111
原因不明自然流产中芳香烃受体与Treg/Th17细胞因子平衡的关系
Relationship between aryl hydrocarbon receptor and the balance of Treg/Th17 cytokines in unexplained spontaneous abortion
摘要
Abstract
Objective:To investigate the expression of aryl hydrocarbon receptor (AhR) in decidua of unexplained spontaneous abortion,and explore the correlation with T regulatory cell (Treg)/Th17 cytokines balance of decidua.Methods:Twenty-three unexplained recurrent spontaneous abortion women were set as the abortion group,while 30 normal early pregnant women as the control group.Quantitative real-time PCR were employed to detect the expression of AhR,forkhead box p3 (Foxp3),IL-10 and retinoic acid receptor-related orphan receptors γ (ROR-γ) mRNA in decidua.The correlation of AhR mRNA with Foxp3,IL-10,ROR-γ mRNA were analyzed.Results:The expression of AhR mRNA and ROR-γ mRNA in decidua in abortion group was significantly higher than that in control group,while Foxp3 mRNA and IL-10 mRNA expression was significantly lower than the control group(both P ＜0.05),AhR mRNA expression was positively correlated with the level of ROR-γ mRNA in two groups(P ＜0.05).However,AhR mRNA expression was not correlated with Foxp3 nor IL-10 mRNA expression in both two groups(both P ＞0.05).Conclusion:In decidua of unexplained spontaneous abortion,Th17 cytokines expression and AhR mRNA expression was increased,with Treg cytokines expression and the ratio of Treg/Th17 decreased,which indicated increasing AhR expression positively correlated with up-regulating Th17 cytokines.关键词
自然流产/芳香烃受体/调节性T细胞/Th17Key words
spontaneous abortion/ aryl hydrocarbon receptor/ T regulatory cell/ Th17分类
医药卫生引用本文复制引用
郭红玲,徐风娟,茅彩萍,庄燕燕,夏飞..原因不明自然流产中芳香烃受体与Treg/Th17细胞因子平衡的关系[J].江苏大学学报（医学版）,2014,24(5):416-419,4.基金项目
江苏省卫生厅课题资助项目(H201311) （H201311）
苏州市临床重点病种诊疗技术专项项目(LCZX201302) （LCZX201302）
