国际医药卫生导报2014，Vol.20Issue(21)：3229-3231,3.DOI:10.3760/cma.j.issn.1007-1245.2014.21.007
血清胰岛素样生长因子-1与早产儿视网膜病发生的关系
Correlation between serum insulin-like growth factor-1 and retinopathy of prematurity
摘要
Abstract
Objective To determine the changes of serum levels of insulin-like growth factor-1 (IGF-1) in the premature infant,and to explore the correlation between serum IGF-1 and retinopathy of prematurity (ROP).Methods Premature infants with gestational age ＜34 weeks or birth weight ＜2000 g were enrolled in the study.They were divided into two groups,ROP group (with ROP) 30 cases,premature control group (without ROP) 30 cases.In the time of first week after delivery,corrected gestational age at 32,34,36 and 40 week,we collected peripheral venous blood and measured the levels of serum IGF-1.At the same time 30 cases of full term newborn were chosen as mature control group.Results Before corrected gestational age of 40 week,serum levels of IGF-lwere rising in ROP group and premature control group.IGF-1 levels of ROP group were significantly lower than those of the premature control group in the first week and corrected gestational age at 32,34,36 week (P ＜ 0.05).IGF-1 levels in ROP group and premature control group were both lower than those of the mature control group in the first week (P ＜ 0.05).At corrected gestational age of 40 week,there was no significant difference among three groups (P ＞ 0.05).Conclusion Low levels of IGF-1 in premature infant may lead to ROP generation in the early period after birth.Improving the serum level of IGF-1 may effectively control the occurrence of ROP during the critical period.关键词
早产儿/视网膜病/胰岛素样生长因子-1Key words
Premature infant/ Retinopathy of prematurity/ Insulin-like growth factor-1引用本文复制引用
丁月琴,陈志凤,赵云开,黄婉文,张素芬..血清胰岛素样生长因子-1与早产儿视网膜病发生的关系[J].国际医药卫生导报,2014,20(21):3229-3231,3.基金项目
东莞市科技计划医疗卫生类科研项目(201110515001099) （201110515001099）
