国际医药卫生导报2014，Vol.20Issue(22)：3375-3379,5.DOI:10.3760/cma.j.issn.1007-1245.2014.22.006
吡格列酮对EH合并IGT患者血管内皮依赖性舒张功能的影响
The effect of Pioglitazone on flow mediated endothelium-dependent dilatation function in patients with essential hypertension and impaired glucose tolerance
摘要
Abstract
Objective To study the effect of Pioglitazone on flow mediated endothelium-dependent dilatation function (FMD) in patients with essential hypertension (EH) and impaired glucose tolerance (IGT) by comparing FMD before and after the therapy of Pioglitazone.Methods 68 patients with EH&IGT were selected and randomly divided into Pioglitazone group (35 cases) and control group (33 cases).Pioglitazone group received Pioglitazone 30 mg once every morning,anti-hypertension therapy,physical exercise and diet control for 12 weeks; while control group received anti-hypertension therapy,physical exercise and diet control only.Measured patients' blood pressure,fasting plasma glucose (FPG),fasting insulin (FINS),2 hours postprandial plasma glucose (2hPG),glycated hemoglobin (HbA1c),blood fat,insulin resistance index [IRI,IRI =(FPG × FINS)/22.5],FMD.Results FMD improved significantly after treatment in Pioglitazone group [(10.38 ± 2.45) vs.(8.96 ± 2.29),P ＜ 0.05],there was no statistically significant difference before and after treatment in control group [(8.83 ± 2.38) vs.(9.08 ± 2.49),P ＞ 0.05].Conclusion Pioglitazone reduced insulin resistance and 2hPG,enhanced FMD.关键词
原发性高血压/糖耐量减低/吡格列酮/血管内皮依赖性舒张功能Key words
Essential hypertension/ Impaired glucose tolerance/ Pioglitazone/ Flow mediated endothelium-dependent dilatation function引用本文复制引用
肖明,谢毅,占松涛,张宝林..吡格列酮对EH合并IGT患者血管内皮依赖性舒张功能的影响[J].国际医药卫生导报,2014,20(22):3375-3379,5.基金项目
广东省东莞市科技局立项项目(201210515020157) （201210515020157）
