国际医药卫生导报2014，Vol.20Issue(23)：3528-3530,3.DOI:10.3760/cma.j.issn.1007-1245.2014.23.007
IL-17在重症肺炎患者外周血的表达及意义
Expression and significance of interleuk-17 in peripheral blood of patients with severe pnemonia
摘要
Abstract
Objective To investigate the expression and connotation of peripheral interleuk-17(IL-17) in patients with severe pnemonia.Methods A total of 56 cases with severe pneumonia were selected in our hospital from June 2013 to June 2014 and were grouped according to Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE IⅡ) scores,patients with lower APACHE Ⅱ score (＜ 20) were divided into group A,otherwise they were included in group B.30 healthy individuals were served as control group.ELISA was utilized to detect the concentrations of IL-17 in peripheral blood of each group and relevant comparative analysis was applied to compare the differences between the groups.Results Level of peripheral IL-17 was significantly increased in patients with severe pneumonia compared with that of control group (P ＜ 0.05).Furthermore,expression of IL-17 increased more significantly in patients with higher APACHE Ⅱ score compared with the lower score group (P ＜ 0.05).Conclusion Patients with severe pneumonia have high expression of IL-17 and the degree of increase is related to the severity of the disease.This study suggests that IL-17 may play a crucial role in the onset and progress of severe pneumonia.关键词
IL-17/重症肺炎/APACHE Ⅱ评分Key words
Interleuk-17/ Severe pneumonia/ Acute physiology and chronic health evaluation Ⅱ引用本文复制引用
黎焯基,成俊芬,陈大勇,梁一波..IL-17在重症肺炎患者外周血的表达及意义[J].国际医药卫生导报,2014,20(23):3528-3530,3.基金项目
湛江市科技攻关计划项目(2014B01036) （2014B01036）
