摘要
Abstract
Objectives To investigate the influence of low doses dexmedetomidine on the quality of cognitive recovery and cardiovascular response in hypertensive patients during extubation after general anesthesia.Methods 80 hypertensive patients (ASA Ⅰ-Ⅱ) scheduled for laparoscopic cholecystectomy were randomly divided into a Dex group (group D) and a control group(group C),40 for each group.Group D were given dexmedetomidine with a loading dose of 0.6 μ g/kg 15 min before the induction intravenously and maintained the operation with a low dose of 0.3 μ g/(kg · h) until 30 min before the end of the operation.Group C were given saline of the same dose intravenously.The breathing recovery time,the extubation time,the cognitive recovery time,the Ramsay sedation score,the Visual Analogue Scale,and the incidence of adverse reactions (cough,restlessness,chills,nausea and vomiting,dizziness and headache,etc.) of both groups were recorded; the changes of hemodynamic parameters such as arterial blood pressure (BP),heart rate (HR),and pulse oxygen saturation (SpO2) of all the patients 30 mins before extubation (T0),at extubation (T1),5 mins after extubation (T2),15 mins after extubation (T3),and 30 mins after extubation (T4) were monitored.Results There were no statistical differences in breathing recovery time,extubation time,and cognitive recovery time between these two groups (P ＞ 0.05).compared with Group C,The Ramsay sedation score was higher,the Visual Analogue Scale and the incidence of adverse reactions were lower,and the cardiovascular responses were significantly fewer in group D than in group C (P ＜ 0.05).The arterial blood pressure(BP) were significantly higher at T1,T2,T3,and T4 than at T0 in group C (P ＜ 0.05).Conclusions Low doses of dexmedetomidine can effectively improve the quality of cognitive recovery in hypertensive patients during extubation after general anesthesia and significantly attenuate the cardiovascular response.关键词
右美托咪定/全麻/拔管期/苏醒质量/心血管反应Key words
Dexmedetomidine/ General anesthesia/ Period of extubation/ Quality of cognitive recovery/ Cardiovascular response
