肿瘤防治研究2014，Vol.41Issue(12)：1279-1281,3.DOI:10.3971/j.issn.1000-8578.2014.12.005
n-3多不饱和脂肪酸灌胃对大鼠结直肠癌的预防作用
Preventive Effect of n-3 Polyunsaturated Fatty Acids Intragastric Administration on Rats Colorectal Cancer
摘要
Abstract
Objective To observe the influence of n-3 polyunsaturated fatty acids(n-3PUFAs) on colorectal cancer of SD rats.Methods A total of 60 SD colorectal cancer rats were randomly divided into two groups,experimental group treated with intragastric administration of n-3PUFAs,and control group treated with the same amount of normal saline.Both groups were given MNU enema.During the experiment,general condition of the rats was observed.After 16 weeks,we dissected the rats and observed the tumors.Tumor pathology was determined by HE sections.The n-3PUFAs concentration of erythrocyte membrane was measured by gas chromatography method in two groups.Results Compared with control group,general condition change was lighter (P＜0.01 or 0.05),n-3PUFAs concentration of red blood cell was higher(P＜0.01) and incidence of cancer was lower (P＜0.05) in experimental group.Conclusion n-3PUFAs could improve general condition and prevent occurrence of colorectal cancer in SD rats.关键词
n-3多不饱和脂肪酸/预防/结直肠癌Key words
n-3 polyunsaturated fatty acids (n-3PUFAs)/ Prevent/ Colorectal cancer分类
医药卫生引用本文复制引用
刘春安,许庆文,何可,徐飞鹏,林琳,黄哲,周才进,朱文劲,王玮尉..n-3多不饱和脂肪酸灌胃对大鼠结直肠癌的预防作用[J].肿瘤防治研究,2014,41(12):1279-1281,3.基金项目
广东省湛江市2011年度财政资金科技专项竞争性分配项目(湛科[2011]79号-58) （湛科[2011]79号-58）
