肿瘤防治研究2014，Vol.41Issue(12)：1300-1303,4.DOI:10.3971/j.issn.1000-8578.2014.12.010
共刺激分子B7-H3在人食管鳞癌中的表达及临床意义
Expression of Costimulatory Molecule B7-H3 in Human Esophageal Squamous Cell Carcinoma and Clinical Significance
摘要
Abstract
Objective To analyze the relationship of B7-H3 expression in human esophageal squamous cell carcinoma (ESCC) and clinicopathological parameters as well as overall survival in ESCC patients.Methods Immunohistochemical assay was applied to evaluate the expression of B7-H3 and the intensity of tumor infiltrating CD8+T lymphocytes in 82 cases of ESCC tissues,corresponding adjacent tissues and esophageal squamous atypical hyperplasia tissues.Results B7-H3 expression was found in 98.8％ (81/82) of ESCC tissues,while it was almost negative in adjacent tissues and atypical hyperplasia tissues.The abnormal expression of B7-H3 was correlated with age,tumor grade and TNM stage (P＜0.05).Meanwhile,B7-H3 expression was negatively correlated with the intensity of tumor infiltrating CD8+T lymphocytes and postoperative prognosis (P＜0.05).Conclusion B7-H3 is overexpressed in ESCC tissues,which is closely correlated with tumor stage.Moreover,B7-H3 overexpression could reflect CD8+T cell infiltration and may help tumor cells avoid immune surveillance.Therefore,B7-H3 plays significant roles in diagnosis,targeted therapeutics and prognosis.关键词
B7-H3/免疫组织化学/人食管鳞癌Key words
B7-H3/ Immunohistochemistry/ Human esophageal squamous cell carcinoma分类
医药卫生引用本文复制引用
曹娜娜,王玲,王珊,单保恩..共刺激分子B7-H3在人食管鳞癌中的表达及临床意义[J].肿瘤防治研究,2014,41(12):1300-1303,4.基金项目
国家自然资金面上项目(81173611) （81173611）
