国际医药卫生导报2015，Vol.21Issue(1)：19-22,4.DOI:10.3760/cma.j.issn.1007-1245.2015.01.006
VitD和DD测定与高血压患者头部静脉血栓的临床研究
VitD and DD determination in hypertensive patients with cerebral venous thrombosis
摘要
Abstract
Objective To research the correlation between the levels of vitamin D (VitD) and D-dimer (DD) and cerebral venous thrombosis in patients with hypertension and to provide some references for health advice.Methods Hypertensive patients were divided into an exercise group and a normal group.Each group's plasma DD level were determined with automatic immune fluorimetry,and serum VitD level ELISA.The results were counted respectively.The patients' life habit was investigated through questionnaires; the patients doing more than 10 km outdoor exercise weekly were set as an exercise group(group A,n=50),others a normal group(group B,n=50).All patients were cranially examined with Doppler ultrasound to judge the formation of head vein thrombosis and the results were compared.All groups' blood pressure were regularly detected for one year to assess the correlation between the levels of VitD and DD and blood pressure in patients with cerebral venous thrombosis.50 healthy people were chosen as a control group(group C).Results The level of DD was (597±163) μtg/L in group A,(615±201) μg/L in group B,and (85±15) μg/L in group C,with statistical differences between groups A and B and group C (P＜0.05).The systolic pressure and diastolic pressure were (144±16) mmHg and (87±9) mmHg in group A,(145±27) mmHg and (89±10) mmHg in group B,and (115±6) mmHg and (71±5) mmHg in group C.The coefficient of variation (CV1) of systolic pressure was 11.4％ in group A,18.9％ in group B,and 6.7％ in group C,with a statistical difference between group A and group B (P＜0.01); the coefficient of variation (CV2) of diastolic pressure was 10.7％ in group A,12.0％ in group B,and 9.4％ in group C,with no statistical difference between group A and group B (P＞0.05).The levels of 25-hydroxyvitamin was (87.8±29.7) nmol/L in group A,(34.9±18.9) nmol/L in group B,and (101.0±25.5) nmol/L in group C,with statistical differences between the three groups (P＜0.05).The level of plasma DD was (1067±189) μtg/L in two patients with cerebral venous thrombosis in group A and (l160±177)μg/L in six patients with cerebral venous thrombosis group B,with no statistical difference (P＞0.05).Conclusions Patients with hypertension not doing exercise group is insufficient or lack of VitD.Discrete degree of systolic blood pressure is significantly narrower patients doing than not doing exercise,but with no statistical difference.Brain micro-thrombosis correlates with plasma DD.Moderate exercise was beneficial for controlling blood pressure and reducing cerebral venous micro-thrombosis.关键词
维生素D/高血压病/收缩压/舒张压/离散度Key words
Vitamin D/ Hypertension/ Systolic pressure/ Diastolic pressure/ Discrete degree引用本文复制引用
古国宁,陈立新,余健全,邓敏..VitD和DD测定与高血压患者头部静脉血栓的临床研究[J].国际医药卫生导报,2015,21(1):19-22,4.基金项目
佛山市卫生科技基金项目(2011048) （2011048）
