中国临床药理学与治疗学2014，Vol.19Issue(12)：1422-1428,7.
miRNA参与肝星状细胞活化及慢性肝病发展的作用机制研究进展
Recent progress in the role of miRNA in hepatic stellate cells activation and the chronic hepatic diseases
摘要
Abstract
Small RNA (known as microRNA,miRNA) is single-stranded non-coding RNA (18-25 nucleotides length),it regulates various proteins by targeting the 3'-untranslated region (3-UTR) of various transcripts,thus dysregulation of miRNA affects a wide range of processes such as cell proliferation and differentiation involved in organ remodeling processes.Current studies demonstrated that post-transcriptional effect of miRNA is involved in the development of chronic liver diseases,while hepatic stellate cells (HSCs) play a vital role in the primary formation of ECM and undergo progressive activation to become myofibroblasts (MFB)-like cells.The aim of this paper is to discuss the role of miRNA in hepatic stellate cells activation and the chronic hepatic diseases.关键词
miRNA/慢性肝病/肝星状细胞Key words
miRNA/ chronic liver diseases/ hepatic stellate cells分类
医药卫生引用本文复制引用
宋立莹,彭向东,王春江,郭韧,刘世坤..miRNA参与肝星状细胞活化及慢性肝病发展的作用机制研究进展[J].中国临床药理学与治疗学,2014,19(12):1422-1428,7.基金项目
中南大学研究生自主探索创新基金项目(2012ZZTS114) （2012ZZTS114）
