江苏大学学报（医学版）2015，Vol.25Issue(1)：57-61,5.DOI:10.13312/j.issn.1671-7783.y140285
雌激素受体α基因多态性与男性不育关系的Meta分析
Meta analysis the association of polymorphisms in estrogen receptor α with male infertility
摘要
Abstract
Objective:To analysis the relationship between two polymorphism genes of estrogen receptor α rs2234693 and rs9340799 and male infertility by Meta-analysis.Methods:We searched PubMed,EMABSE,CNKI and WanFang database,while 24 articles were concluded.Meta analysis was performed using Stata 11.0 software.Calculated the odds ratio and 95％ confidence interval and evaluated the strength of the associations,sensitivity and publication bias.Results:For the rs2234693,there were significant association in the comparison of CC vs.TT (OR =0.72,95％ CI:0.54-0.96),CT vs.TT (OR=0.74,95％ CI:0.58-0.94) and (CC+CT) vs.TT (OR=0.73,95％ CI:0.58-0.91)with male infertility.For rs9340799 polymorphism,increased risks were observed for the comparison of AAvs.GG(OR=1.67,95％ CI:1.21-2.32) and AA vs.(GA+GG) (OR=1.63,95％ CI:1.32-2.03).Conclusion:The rs2234693 CC genotype was associated with the decreased risk for male infertility; however,the rs9340799 AA genotype was associated with an increased risk for male infertility.关键词
雌激素受体α/男性不育/基因多态性Key words
estrogen receptor α/male infertility/polymorphisms分类
医药卫生引用本文复制引用
李天赋,周青,张翠,蒋卫军,吴秋月,李卫巍,许豪勤,夏欣一..雌激素受体α基因多态性与男性不育关系的Meta分析[J].江苏大学学报（医学版）,2015,25(1):57-61,5.基金项目
江苏省科技专项基金资助项目(BM2013058) （BM2013058）
