中国医学创新Issue(21)：45-47,48,4.DOI:10.3969/j.issn.1674-4985.2014.21.014
右美托咪定联合超低剂量纳洛酮预防瑞芬太尼麻醉诱发术后痛觉过敏的临床研究
Clinical Study of Dexmedetomidine and Ultra-low Dose Naloxone for Prevention and Control Hyperalgesia after Remifentanil Anesthesia
摘要
Abstract
To research the clinical significance of dexmedetomidine and ultra-low dose naloxone for prevention and control hyperalgesia after remifentanil anesthesia.Method:60 female patients scheduled for endoscopic sinussurgery(ASA I orⅡ)were randomly divided into three groups,the remifentanil group(the group R), remifentanil combined dexmedetomidine group(the group RD),remifentanil combined dexmedetomidine +naloxone micro pump injection group(the group RD+N),each group had 20 cases. All groups were given intravenous infusion of 0.1-0.3 µg/(kg·min)remifentanil,combined with propofol infusion of 4-12 mg/(kg·h),which doses were adjusted according to the operation needs and hemodynamics data during operation. The patients in the group RD(remifentanil and dexmedetomidine)were given intravenous injection of 0.6 µg/kg with mini-pump for 15 min utes after the intubation, then reduced to 0.4 µg/(kg·h). Based on the use in the group RD,the patients in group RD+N(remifentanil and dexmedetomidine combined with ultra-low dose naloxone)were given intravenous infusion of 0.1 µg/(kg·h)until the end of the operation. The patients in the group R(remifentanil)were given intravenous injection of equal normal saline. The surgery duration,extubation time,OAA/s scores after extubation,VAS scores at 15,30 min,1,2,4,12 h after operation were record,and incidence of adverse effects were recorded.Result:Compared with the R,RD group, VAS scores in the group RD+N were significantly decreased,time of extubation was earlier,OAA/S sores were lower, fewer complications at each time,the differences had statistical significance(P<0.05).Conclusion:Dexmedetomidine combined with ultra-low dose naloxone can effectively prevent hyperalgesia after remifentanil anesthesia,shorten the recovery time,obtain good postoperative analgesia,the combination of both can reduce nausea,vomiting,chills and other complications.关键词
右美托咪定/超低剂量纳洛酮/瑞芬太尼/痛觉过敏Key words
Dexmedetomidine/Ultra-low dose naloxone/Remifentanil/Hyperalgesia引用本文复制引用
王智钧,谭素云,肖圣华,刘永宏,韩全国,卢钊楷..右美托咪定联合超低剂量纳洛酮预防瑞芬太尼麻醉诱发术后痛觉过敏的临床研究[J].中国医学创新,2014,(21):45-47,48,4.基金项目
东莞市科技计划医疗卫生类科研一般项目 （）
