中国普通外科杂志2015，Vol.24Issue(2)：258-264,7.DOI:10.3978/j.issn.1005-6947.2015.02.020
择期腹腔镜胆囊切除术预防性使用抗生素的作用Meta分析
Efficacy of antibiotic prophylactic regimens in elective laparoscopic cholecystectomy：a Meta-analysis
汪超 1黄强 1林先盛 1刘臣海 1杨骥 1胡俊1
作者信息
- 1. 安徽医科大学附属省立医院 普外科胆胰外科/肝胆胰安徽省重点实验室，安徽 合肥 230001
- 折叠
摘要
Abstract
Objective: To evaluate the effcacy of antibiotic prophylactic regimens in elective laparoscopic cholecystectomy.
<br> Methods: The randomized controlled trials (RCTs) concerning use of prophylactic antibiotics in elective laparoscopic cholecystectomy publicly published between January 2003 and December 2013 were collected by searching the relevant online databases. Atfer literature screening according to inclusion and exclusion criteria, data extraction and methodological quality evaluation, a Meta-analysis was performed using RevMan 5.2.10 sotfware.
<br> Results: Nine RCTs were ifnally included, involving 2 316 patients with 1 165 cases in prophylactic group and 1 151 cases in control group. The results of Meta-analysis-based comparison between prophylactic group and control group showed no statistical difference (allP>0.05) in terms of the overall postoperative infection rate (RR=0.98, 95%CI=0.59–1.61), superifcial incisional surgical site infection rate (RR=0.82, 95%CI=0.48–1.41) and positive rate of bile culture (RR=0.82, 95%CI=0.64–1.05), as well as no statistical difference in the overall postoperative infection rate and superficial incisional surgical site infection rate in the included RCTs that recruited patients with diabetes and biliary colic (bothP>0.05).
<br> Conclusion: Antibiotics for prophylaxis cannot reduce the incidence of postoperative infection in elective laparoscopic cholecystectomy, but this conclusion still needs to be proven by large sample and multicenter prospective RCTs.关键词
胆囊切除术,腹腔镜/抗生素预防/Meta分析Key words
Cholecystectomy, Laparoscopic/Antibiotic Prophylaxis/Meta-Analysis分类
医药卫生引用本文复制引用
汪超,黄强,林先盛,刘臣海,杨骥,胡俊..择期腹腔镜胆囊切除术预防性使用抗生素的作用Meta分析[J].中国普通外科杂志,2015,24(2):258-264,7.
