摘要
Abstract
Objective:To investigate the expression of Polo-like kinase 1 (PLK1) in cervical squamous cell carcinoma (SQCC) and its clinical significance.Methods:The immunohistochemical staining method was conducted to detect the expression of PLK1 in 34 cases of cervical squamous epithelium,82 cases of cervical SQCC,166 cases of cervical intraepithelial neoplasia (CIN),including 48 cases of CIN I,42 cases of CIN Ⅱ and 76 cases of CIN Ⅲ/carcinoma in situ.And the correlation of PLK1 expression and clinicopathologic factors of cervical SQCC was analyzed.Results:There was significant difference in the expression rate of PLK1 among cervical squamous epithelium,CIN I,CIN Ⅱ,CIN Ⅲ/carcinoma in situ and cervical SQCC,which was 14.71％,22.92％,35.71％,69.74％ and 86.59％,respectively (χ2 =87.42,P ＜0.01).The overexpression of PLK1 in cervical SQCC was significant correlated with the pathologic grade,FIGO clinical stage (both P ＜ 0.05),whereas uncorrelated with patient age,high-risk human papillomavirus infection,pelvic lymphatic metastasis and recurrence/metastasis (both P ＞ 0.05).In cervical SQCC,there was significant difference in the survival curves between the patients with high PLK1 expression and those with low or negative PLK1 expression (P ＜ 0.05).Conclusion:The PLK1 over-expression might involve in the development,invasion and metastasis and could be used as a prognostic factor of cervical SQCC.关键词
宫颈肿瘤/鳞状细胞癌/Polo样激酶1/免疫组织化学Key words
uterine cervical neoplasm/squamous cell carcinoma/Polo-like kinase 1/immunohistochemistry分类
医药卫生
