摘要
Abstract
Objective To study the antioxidative protection of Gypenosides in aged mices skin. Methods 60 mices were selected and randomly divided into 3 groups:young control group (group A),aged control group (group B) and aged dose group (group C). In group A and group B,normal saline (20ml/kg) was given intragastricly. Gypenosides extracts at doses of 8g/kg was administered intragastricly in group C,once a day. Skin tissue from treated mices were prepared for analysis 30 days after treatments. Relative level changes of MDA,SOD,CAT and GSH- Px were measured. Results Increases in MDA and decreases in SOD,CAT and GSH- Px were observed in both group B and group C as compared with group A ( <0.05). Compared with mices in group B, mices in group C showed significant decreases in MDA and increases in SOD,CAT and GSH- Px ( <0.05). Conclusion Intragastric administration of Gypenosides extracts to mices could alleviate the oxidative injury to aged skin,and therefore could delay the skin aging in mices.关键词
绞股蓝皂苷/抗氧化损伤/皮肤衰老Key words
Gypenosides/antioxidative injury/aged skin分类
医药卫生
