中国美容医学Issue(5)：40-46,7.
基质金属蛋白酶-2、14及RECK基因在涎腺多形性腺瘤的初发、复发及恶变中的表达及意义
Expression of RECK Gene and Matrix Metalloproteinase-2,Matrix Metalloproteinase-14 in the Primary Plemorphic Adenoma(PA),Recurrent PA and Malignant PA
阿依努尔·艾比布拉 1陈青立 1林兆全 1尹小朋 1龚忠诚 1刘慧 1凌彬 1克热木·阿巴斯 1胡露露 1宁晓婷 1杨萌1
作者信息
- 1. 新疆医科大学第一附属医院颌面肿瘤外科 新疆医科大学口腔医学院 新疆维吾尔自治区口腔医学研究所 新疆 乌鲁木齐 830054
- 折叠
摘要
Abstract
Objective To investigate the expression and significance of RECK gene and Matrix Metalloproteinase- 2(MMP- 2),Matrix Metalloproteinase- 14(MMP- 14) in the primary plemorphic adenoma(PA), recurrent PA and malignant PA. Methods Fifty samples including 36 primary PA,7 recurrent PA,7 malignant PA and 10 normal parotid glands as control were examined immunohistocheemically.Among the 10 PA samples,there were all samples originated from parotid gland.RECK gene,MMP- 2 and MMP- 14 were decected immunohistochemically and semi-quantitively in these samples.All date were analyzed through SPSS 21.0 software. Results MMP-2 has significant difference in normal group and recurrent group(P<0.05),the difference was statistically significant in normal group and the malignant group (P<0.05);the difference was statistically significant in primary group and recurrent group(P<0.05);the difference was statistically significant in primary group and the malignant group(P<0.05).The expression of RECK and MMP-2 and MMP-14 were negative correlation,respectively,in normal parotid gland,primaryPA,recurrent PA and maligant PA(r=-0.887,P<0.05;r=0.798,P<0.05). Conclusion Clinically,in the tissue of the salivary glands,PA will relapse.When examined both RECK and MMP- 2 have significant meaning.Through this examination,tumor aggressiveness and prognosis can be indicated.关键词
涎腺/多形性腺瘤/MMP-2/MMP-14/RECK/免疫组化Key words
Salivary glands/Pleomorphic adenoma/MMP-2/MMP-14/RECK/Immunohistochemisty分类
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阿依努尔·艾比布拉,陈青立,林兆全,尹小朋,龚忠诚,刘慧,凌彬,克热木·阿巴斯,胡露露,宁晓婷,杨萌..基质金属蛋白酶-2、14及RECK基因在涎腺多形性腺瘤的初发、复发及恶变中的表达及意义[J].中国美容医学,2015,(5):40-46,7.
