摘要
Abstract
Objective To discuss the diagnostic value of the ratios of N-terminal B-type brain natriuretic peptide precursor (NT-proBNP) and serum creatinine (SCr),serum cystatin C (SCys-C) in chronic kidney disease (CKD) combined with heart failure.Methods CKD patients (part with heart failure) in our hospital were randomly selected and distinguished CKD1-5 period,each period divided into heart failure group and without heart failure group,people without CKD as control group.Collected peripheral venous blood of all groups at the same time to measure blood urea nitrogen (BUN),SCr,SCys-C,NT-proBNP and NT-proBNP/SCr,NT-proBNP/SCys-C.Did correlation analysis between NT-proBNP,NT-proBNP/SCr,NT-proBNP/SCys-C and phase CKD1-5,BUN,SCr,SCys-C and GFR in without heart failure group,and did multiple cross comparison research among NT-proBNP,NT-proBNP/SCr,NT-proBNP/SCys-C in each group.Results NT-proBNP was significantly correlated with phase CKD1-5,BUN,SCr,SCys-C,GFR in without heart failure group (P＜0.01),while NT-proBNP/SCr,NT-proBNP/SCys-C were not.In phase CKD1-5 and control group,NT-proBNP,NT-proBNP/SCr,NT-proBNP/SCys-C in heart failure group were all significantly higher than those in without heart failure group (P＜0.01).NT-proBNP significantly increased as the progress of CKD stage in heart failure group and without heart failure group of phase CKD1-5 (P＜0.05),NT-proBNP/SCr and NT-proBNP/SCys-C significantly decreased as the progress of CKD stage in heart failure group of phase CKD1-5 (P＜0.05).NT-proBNP/SCr was ＞10.58,NT-proBNP/SCys-C ＞1012.22 in phase CKD1-5.Conclusion NT-proBNP/ SCr,NT-proBNP/SCys-C can be clinical indexes of independently evaluating CKD combined with heart failure,not affected by kidney function.关键词
慢性肾脏病/心力衰竭/氨基末端/B型脑钠肽前体/血清肌酐/诊断价值Key words
Chronic kidney disease/Heart failure/Amino terminal/B-type brain natriuretic peptide precursor/Serum creatinine/Diagnostic value
