国际医药卫生导报2015，Vol.21Issue(14)：2050-2052,3.DOI:10.3760/cma.j.issn.1007-1245.2015.14.033
联合检测ADA、CA125和CEA对结核性与恶性胸腔积液的诊断价值
Clinical application of combined detection of ADA, CA125 and CEA in tuberculous pleural effusion and malignant pleural effusion
韩冰 1李英煜 1周宇 1宋其生 1于滨 1高阳1
作者信息
摘要
Abstract
Objective To assess the clinical value of combined detection of fluidadenosine deaminase (ADA),carbohydrate antigen 125 (CA125) and carcinoembryonic antigen (CEA) in the differential diagnosis of tuberculous and malignant pleural effusion.Methods The activity of ADA in pleural effusion was determined by the method of continuous monitoring with enzyme and the levels of CA125 and CEA were detected by chemiluminescence immune analysis in both 82 patients with tuberculous pleural effusion and 56 patients with malignant pleural effusion,and the results were comprehensively analyzed.Results The average content of ADA in tuberculous pleural effusion was significantly higher than that in malignant pleural effusion,while the levels of CEA and CA125 were significantly lower than those in malignant pleural effusion (P＜0.05).If the cut-off value of ADA was more than 40 U/L in the diagnosis of tuberculous pleural effusion,its sensitivity,specificity and accuracy were 82.8％,80.4％ and 81.7％ respectively.If the cut-off value of CA125 was more than 35 U/ml,the sensitivity,specificity and accuracy for diagnosis of malignant pleural effusion were 82.6％,58.8％ and 65.4％ respectively.If the cut-off value of CEA was more than 5μg/L,the sensitivity,specificity and accuracy for diagnosis of malignant pleural effusion were 71.7％,82.8％ and 76.0％ respectively.The sensitivity and accuracy of combination of CA125 and CEA for diagnosis of malignant pleural effusion was 93.5％ and 81.7％,Which were higher than those of either CA125 or CEA (P＜0.05).Conclusion The combined detection ofADA,CEA and CA125 has an important reference value for early differential diagnosis of tuberculous and malignant pleural effusion.关键词
胸腔积液/腺苷脱氨酶/肿瘤标志物/癌胚抗原/糖类抗原-125Key words
Pleural effusion/Adenosine deaminase/Tumor marker/Carcinoembryonic antigen/Carbohydrate antigen-125引用本文复制引用
韩冰,李英煜,周宇,宋其生,于滨,高阳..联合检测ADA、CA125和CEA对结核性与恶性胸腔积液的诊断价值[J].国际医药卫生导报,2015,21(14):2050-2052,3.
