广东医学Issue(1)：8-11,4.
雌激素α受体 PvuⅡ和 XbaⅠ基因多态性与产后抑郁障碍的相关性
The polymorphisms of Pvu Ⅱ and Xba Ⅰ genes of the estrogen receptor in women with postpartum depression disorder
摘要
Abstract
Objective To investigate the correlation between the polymorphisms of estrogen receptor -α(ERα) and postpartum depression disorder (PPD), to provide genetic evidences for the etiology and pathogenesis of PPD , ant to provide the theory basis for diagnosis and therapy for PPD .Methods 45 cases (depressed group) and 45 controls (con-trol group) were selected according questionnaires .PCR -RFLP was applied to examine the polymorphisms of Pvu Ⅱ and XbaⅠ in ERα.Allele frequency was assessed using genetic numeration .The correlations between the polymorphisms of PvuⅡ and XbaⅠ and PPD using SPSS 18.0.Results The chi -square test revealed that the genotype distributions of PvuⅡ in ERαin depressed group and control group were significantly different , so were the allele frequencies (P and p, P <0.05).There was no significant different in genotype distribution or allele frequency (X and x) of XbaⅠ in ERαbe-tween depressed group and control group (P >0.05).Conclusion There is correlation between polymorphism of ER αPvuⅡ and PPD, while no correlation between genetic mutation of Xba Ⅰ and PPD is revealed.The analysis of the joint genotype shows that the general genotype distributions in depressed group and control group are similar .关键词
产后抑郁/雌激素α受体/基因多态性/XbaⅠ/PvuⅡKey words
postpartum depression disorder/estrogen receptor -α/gene polymorphisms/Xba Ⅰ/Pvu Ⅱ引用本文复制引用
夏光源,张静,谢渊,陈静,邹涛..雌激素α受体 PvuⅡ和 XbaⅠ基因多态性与产后抑郁障碍的相关性[J].广东医学,2015,(1):8-11,4.基金项目
贵州省科技计划课题 （）
