广东医学Issue(7)：985-988,4.
胰岛素样生长因子－1受体抑制剂 AG1024对鼻咽癌移植瘤的放射增敏效应
Radiosensitizing effects of insulin like growth factor-1 receptor inhibitor on the transplanted tumor of nasopha-ryngeal carcinoma in nude mice
摘要
Abstract
Objective To study the radiosensitizing effects of AG1024, the insulin like growth factor-1 receptor (IGF-1R) inhibitor, on the transplanted tumor of nasopharyngeal carcinoma (NPC) in nude mice.Methods The transplanted tumor models of human CNE2 NPC in nude mice were established and randomly divided into four groups, the control, the AG1024, the radiation and the combination therapy groups.The latter three groups were treated with AG1024, radiotherapy, AG1024 combined with radiotherapy, respectively.The growth of transplanted tumor was recor-ded.The apoptosis were examined by flow cytometry.The mRNA expression of PCNA and survivin in tumor samples was assessed by RT-PCR.Results Significant inhibitive effect was observed in combination therapy group, with significantly higher apoptosis rate when comparing with the other 3 groups (P<0.05).Expression levels of PCNA and survivin in the combination therapy group were significantly lower than those in the other 3 groups(P<0.05).Conclusion The combi-nation therapy has obviously higher curative efficacy than simple therapy, providing theoretic and clinical basis for the re-search of combination of targeting treating and radiotherapy.关键词
胰岛素样生长因子-1受体/鼻咽癌/放射增敏Key words
insulin like growth factor-1 receptor/nasopharyngeal carcinoma/radiosensitivity引用本文复制引用
伍方财,卢汉桂..胰岛素样生长因子－1受体抑制剂 AG1024对鼻咽癌移植瘤的放射增敏效应[J].广东医学,2015,(7):985-988,4.基金项目
广东省汕头市医疗重点科技计划项目 （）
