中国组织工程研究Issue(46)：7498-7502,5.DOI:10.3969/j.issn.2095-4344.2014.46.024
阴部神经电刺激干预脊髓损伤后神经源性膀胱：功能重建的文献研究
Electrical stimulation of the pudendal nerve for neurogenic bladder dysfunction after spinal cord injury：a literature research on functional reconstruction
摘要
Abstract
BACKGROUND:Stimulation of the pudendal nerve as a target can improve neurogenic bladder dysfunction after spinal cord injury, by adjusting the frequency, intensity, pulse width, as wel as regulating synergistic effect of detrusor and urethral sphincter. OBJECTIVE: To assess the research status of electrical stimulation of the pudendal nerve in the treatment of neurogenic bladder dysfunction after spinal cord injury. METHODS: We searched the folowing databases for articles addressing electrical stimulation of the pudendal nerve for neurogenic bladder dysfunction after spinal cord injury: PubMed, Cochrane Central Register of Controled Trials (CENTRAL), China National Knowledge Infrastructure, Wanfang Database, and VIP Database. The search was updated to July 2014, and the reference lists of the identified studies were manualy screened for additional studies. The study selection and data extraction were independently conducted by two reviewers. RESULTS AND CONCLUSION:Fourteen studies were included in this review. We derived the folowing points by analyzing the included studies: Electrical stimulation of the pudendal nerve has positive effects on rehabilitation of neurogenic bladder dysfunction after spinal cord injury; pudendal nerve electrical stimulation can modulate the coordination of the detrusor and the external urethral sphincter, improve the bladder compliance and restore bladder function by regulating pudendal-to-bladder reflex and spinal reflexes to the bladder. Electrical stimulation of the pudendal nerve may be potentialy implemented as a feasible treatment of neurogenic bladder dysfunction after spinal cord injury. More high quality researches should be conducted to clarify the efficacy and the potential active mechanisms of pudendal nerve electrical stimulation for neurogenic bladder dysfunction after spinal cord injury because the number of clinical reports published in this study area is limited, neurophysiological mechanisms underlying biphasic regulation of frequency on bladder function are not wel known, and which intensity of pudendal nerve electrical stimulation is more effective than others for the treatment of neurogenic bladder dysfunction after spinal cord injury remains unknown.关键词
组织构建/组织工程/阴部神经电刺激/神经源性膀胱/脊髓损伤Key words
spinal cord injuries/electric stimulation therapy/urinary bladder/neurofeedback分类
医药卫生引用本文复制引用
谢斌,岳雨珊,朱毅,王建伟,程洁..阴部神经电刺激干预脊髓损伤后神经源性膀胱：功能重建的文献研究[J].中国组织工程研究,2014,(46):7498-7502,5.基金项目
江苏省高校优势学科建设工程资助项目；南京中医药大学中医学一级学科开放课题(YS2012ZYX408)；南京中医药大学国家基金预研基金项目(13XYYZ3) （YS2012ZYX408）
