中国组织工程研究Issue(47)：7653-7658,6.DOI:10.3969/j.issn.2095-4344.2014.47.020
静电纺三维结构组织工程支架：应用中的问题与发展前景
Three-dimensional tissue engineering scaffolds with electrospinning technique：application and prospects
摘要
Abstract
BACKGROUND:The electrospinning technique has been used to prepare biological scaffolds to simulate nano-fiber structure of extracelular matrix; therefore, widespread attention has been paid to the electrospinning technique in the field of regenerative medicine and tissue engineering. OBJECTIVE: To review the articles about increasing electrospun nanofiber scaffold porosity, enlarging pore diameter, promoting cel infiltration with related technologies, in order to discover the most practical and economical technology. METHODS:The first author retrieved CNKI database, Wanfang database and PubMed with the keywords of “cel infiltration, 3D scaffold, electrospinning” in Chinese and English, respectively. Literature retrieval period was from January 2004 to October 2014. RESULTS AND CONCLUSION:Electrospinning technology is the most effective method for preparation of nanofiber scaffolds. Electrospinning scaffolds as tissue engineering scaffolds have become an issue of concern in the basic research year by year. However, the internal nano-scale pore of nanofiber scaffolds limits the cels to grow on the surface, so recent research has been focused on highly porous three-dimensional structure which can promote the permeable growth of cels instead of two-dimensional scaffolds. Several techniques have been used, which go from the adjustment of materials and speed of electrospinning to the applications of various kinds of complicated machines. However, the existing researches are stil not mature and stable, the majority of which are applied onlyin vitro as cel implantation or subcutaneous implantation in smal animals. The above-mentioned methods stil need long-term comparative studies to confirm the feasibility in the tissue-engineered repair of organs.关键词
生物材料/纳米材料/静电纺/细胞渗透/三维结构/组织工程/支架Key words
tissue engineering/stents/nanofibers分类
医药卫生引用本文复制引用
张楷乐,王营,郭旭然,陈剑锋,莫秀梅,傅强,陈嵘..静电纺三维结构组织工程支架：应用中的问题与发展前景[J].中国组织工程研究,2014,(47):7653-7658,6.基金项目
上海市科委基础研究领域项目(14JC1492100)同轴共纺结合水纺技术制备载药纳米纱抑制组织工程尿道纤维化的实验研究 （14JC1492100）
