中国组织工程研究Issue(47)：7659-7665,7.DOI:10.3969/j.issn.2095-4344.2014.47.021
组织工程膀胱支架材料：应用现状及血管化策略
Bladder tissue engineering scaffold：its application and vascularized strategies
摘要
Abstract
BACKGROUND:Along with the increasing improvement of bladder tissue engineering research, the vascularization of tissue-engineered bladder after implantation becomes an issue of concern. OBJECTIVE: Combined with relevant literature in recent years, to review the choice, design and application of scaffold materials for bladder tissue engineering as wel as vascularized strategies folowing implantation. METHODS:The first author retrieved PubMed database and CNKI databases for articles relevant to biological scaffold materials in bladder tissue engineering and vascularization of tissue-engineered bladder published between January 2000 to September 2014 using the keywords of “tissue engineering; bladder; biomaterials/scaffolds; vascularization” in English and Chinese, respectively. RESULTS AND CONCLUSION: Recently, the biological scaffolds for bladder tissue engineering include two main categories: natural biomaterials and synthetic polymers. The major target of bladder tissue engineering remains to prepare the best cel-seeded scaffolds, to determine the best source of stem cels, to explore the best differentiation way of stem cels, and to promote angiogenesis and nerve regeneration of implanted scaffolds. Thereinto, promoting vascularization of scaffold materials and building complex tissues is most chalenging. At present, it is stil difficult to precisely control the directional proliferation, migration and differentiation of the attached endometrial cels. Although the vascular network is necessary for the nutrient supply and metabolic waste removal of cels or tissues, strategies to promote angiogenesis or vasculogenesis are stil limited.关键词
生物材料/纳米材料/组织工程膀胱/支架/血管化/国家自然科学基金Key words
tissue engineering/bladder/tissue scaffolds分类
医药卫生引用本文复制引用
祁娜,黎丽茜,田虹..组织工程膀胱支架材料：应用现状及血管化策略[J].中国组织工程研究,2014,(47):7659-7665,7.基金项目
国家自然科学基金(31271043)；课题名称应用生物打印技术制备工程膀胱组织 （31271043）
