中国组织工程研究Issue(50)：8108-8112,5.DOI:10.3969/j.issn.2095-4344
骨髓间充质干细胞膜片复合自体髂骨移植修复牙槽嵴裂
Bone mesenchymal stem cell sheet transplantation combined with autologous iliac bone for repair of alveolar cleft
摘要
Abstract
BACKGROUND:Autogenous iliac bone graft for repair of alveolar cleft often cannot achieve a stable therapeutic effect, and the graft resorption rate varies with each individual that is influenced by many factors. <br> OBJECTIVE:To observe the bone resorption after bone marrow mesenchymal stem cel sheet transplantation with autogenous iliac cancelous bone for alveolar cleft repair. <br> METHODS:Bilateral alveolar cleft models were prepared in dogs. Using the self-control method, bone marrow mesenchymal stem cel sheet combined with autogenous iliac bone (experimental group) and autogenous iliac bone alone (control group) were respectively implanted into the bilateral alveolar clefts. Mandible CT and microCT were used to compare the bone resorption rate, bone volume fraction, trabecular thickness, trabecular separation, and bone mineral density. <br> RESULTS AND CONCLUSION:The bone resorption rate was significantly lower in the experimental group than the control group at 3 and 6 postoperative months (P < 0.01); while, the bone volume fracture and bone mineral density of the experimental group were significantly higher than those in the control group at postoperative 6 months (P < 0.05), but the trabecular separation of the experimental group was significantly lower than that in the control group (P < 0.05). In addition, there was no difference in the trabecular thickness between the two groups (P > 0.05). These findings indicate that bone marrow mesenchymal stem cel sheet transplantation combined with autogenous iliac bone graft can reduce bone resorption rate and meanwhile, promote new bone formation.关键词
干细胞/移植/细胞膜片/骨髓间充质干细胞/自体髂骨移植/牙槽嵴裂/骨吸收率Key words
bone marrow/mesenchymal stem cels/ilium/bone transplantation/transplantation, autologous/maxilofacial abnormalities分类
医药卫生引用本文复制引用
沈悦,马海英,张彦升,王娟,时炳正..骨髓间充质干细胞膜片复合自体髂骨移植修复牙槽嵴裂[J].中国组织工程研究,2014,(50):8108-8112,5.基金项目
the Science and Technology Supporting Plan of Hebei Province, No.1213078ZD （）
