中国组织工程研究Issue(51)：8275-8280,6.DOI:10.3969/j.issn.2095-4344
白细胞介素17在肾移植排斥反应中的表达及意义
Expression and significance of interleukin-17 in rejection after kidney transplantation
摘要
Abstract
BACKGROUND:Interleukin-17 is a potent inflammatory cytokine, which has been greatly reported in acute rejection research but little in chronic rejection or acute and chronic rejection research. <br> OBJECTIVE:By studying the correlation between interleukin-17 and renal alograft rejection, to explore the asociation between interleukin-17 and rejections. <br> METHODS: In accordance with the inclusion criteria strictly, health physical examination persons (15 caess) and kidney transplantation recipients (47 caess) were choosed and divided into four groups: normal group (15 cases), stable renal function group (20 cases), acute rejection group (15 cases), and chronic rejection group (12 cases). The relative expression levels of interleukin-17 mRNA in peripheral blood mononuclear cels of these four groups were detected by real-time fluorescence quantitative PCR. Then differences between four groups were compared and the correlations with the serum creatinine and the rejection time were analyzed. <br> RESULTS AND CONCLUSION:The expression levels of interleukin-17 mRNA in the acute rejection and stable renal function groups were signficantly different from that in the normal group. The expression level of interleukin-17 mRNA in the chronic rejection group was increased by 2.89 times, showing a significant difference from the stable group (P < 0.01). In the acute and chronic rejection groups, the expression level of interleukin-17 mRNA had no significant correlation with serum creatinine level and postoperative rejection time. These findings indicate that interleukin-17 is of significance in renal alograft rejection.关键词
组织构建/移植/白细胞介素17/肾移植/急性排斥反应/慢性排斥反应/实时荧光定量PCR/单个核细胞/血清肌酐/排斥时间/国家自然科学基金Key words
Subject headings:interleukins/graft rejection/kidney transplantation/lymphocytes分类
医药卫生引用本文复制引用
孙曙,石炳毅,李州利,蔡明,王强,金海龙,陈昌庆,刘志佳,孔祥瑞,李聪然..白细胞介素17在肾移植排斥反应中的表达及意义[J].中国组织工程研究,2014,(51):8275-8280,6.基金项目
Funding:theNational Natural Science Foundation of China, No.81171753 （）
