中国组织工程研究Issue(51)：8346-8352,7.DOI:10.3969/j.issn.2095-4344
血管生成相关因子与瘢痕增生
Cytokines related to angiogenesis in scar hyperplasia
吴子涵 1李高峰1
作者信息
- 1. 湖南师范大学第一附属医院湖南省人民医院，湖南省长沙市 410006
- 折叠
摘要
Abstract
BACKGROUND:Scar is the product of wound healing. Severe scar hyperplasia often leads to the deformity and dysfunction. The scar generates along with angiogenesis. Angiogenesis is closely related to the formation of scar. Cytokines are involved in the scar formation. <br> OBJECTIVE:To summarize the relationship between the cytokines of angiogenesis and scar hyperplasia and to understand the cytokines of angiogenesis effect on scar hyperplasia and atrophy by influencing the angiogenesis and vascular maturity during scar formation, thereby providing a new theoretical basis and measures for clinical prevention and treatment of scar. <br> METHODS:A computer-based online search of PubMed, Medline and CNKI databases was performed for acquiring relevant articles in English and Chinese, respectively, by using the key words of “scar, angiogenesis, cytokines”. Fifty-four articles were included which related to angiogensis in scar hyperplasia, cytokines in scar hyperplasia and cytokines of angiogensis. <br> RESULTS AND CONCLUSION:The formation of scar is a result of the combined action of various complex factors, which is influenced by many factors. The scar generates along with agiogenesis and vascular maturity. The cytokines of angiogenesis influence angiogenesis and vascular maturity, and thus affect the scar hyperplasia and atrophy. By intervening the expression or function of the cytokines of angiogenesis to affect the angiogenesis and vascular maturity, we can prevent and treat scar in the clinic.关键词
组织构建/组织工程/瘢痕/血管生成/血管成熟/细胞因子/瘢痕增生/微循环/微环境/缺氧/机制/瘢痕防治Key words
Subject headings：scar/angiogenesis/cytokines分类
医药卫生引用本文复制引用
吴子涵,李高峰..血管生成相关因子与瘢痕增生[J].中国组织工程研究,2014,(51):8346-8352,7.
