中国组织工程研究Issue(52)：8414-8419,6.DOI:10.3969/j.issn.2095-4344
不同药物洗脱支架置入老年急性非ST段抬高型冠脉综合征后的炎症因子反应
Effects of different drug eluting stents on inflammatory factors in elderly patients with non-ST-segment elevation acute coronary syndrome
摘要
Abstract
BACKGROUND:Rapamycin eluting stent and its derivative-the everolimus eluting stent can improve the general inflammatory reaction after stent implantation in patients with acute coronary syndrome, and reduce the incidence of restenosis. Firebird stent as a domestic rapamycin eluting stent is currently the most widely used in China, while XIENCE.V stent as an everolimus eluting stent is the most widely used <br> OBJECTIVE: To compare the effects of domestic Firebird stent and imported XIENCE.V stent on serum high-sensitivity C-reactive protein and interleukin-6 levels after stent implantation in elderly patients with non-ST segment elevation acute coronary syndrome. <br> METHODS: Totaly 112 elderly patients with non-st segment elevation acute coronary syndrome, including 65 cases of acute non-ST segment elevation myocardial infarction and 47 cases of unstable angina pectoris, were enroled from September 2012 to July 2014. After 72 hours medical treatment, the patients were subject to percutaneous coronary intervention and divided into two groups: Firebird stent group and XIENCE.V stent group. <br> RESULTS AND CONCLUSION:There was no difference in the levels of serum high-sensitivity C-reactive protein and interleukin-6 between the two groups after stent implantation. The serum high-sensitivity C-reactive protein and interleukin-6 levels at 24 hours after stenting were significantly increased in each group compared with the baseline (P < 0.01), while the levels of high-sensitivity C-reactive protein and interleukin-6 were declined significantly after 1 month of stent implantation (P < 0.05). However, there was no difference in the levels of serum high-sensitivity C-reactive protein and interleukin-6 between the two groups at 24 hours, 1 week, and 1 month after stent implantation. No cardiac accidents occurred in the two groups during and 1 month after percutaneous coronary intervention and stent implantation. Two groups had similar security and histocompatibility. The results confirm that both of Firebird stent and XIENCE.V stent can inhibit inflammatory responses and have similar clinical efficacy in elderly patients with non-ST segment elevation acute coronary syndrome.关键词
Subject headings：tissue engineering/C-reactive protein/stents/interleukin-6Key words
Subject headings：tissue engineering/C-reactive protein/stents/interleukin-6分类
医药卫生引用本文复制引用
卢妙,王向明,王森,周传伟..不同药物洗脱支架置入老年急性非ST段抬高型冠脉综合征后的炎症因子反应[J].中国组织工程研究,2014,(52):8414-8419,6.基金项目
国家青年自然科学基金(81100123)Funding：the National Natural Science Foundation of China for the Youth, No.81100123 （81100123）
