中国组织工程研究Issue(52)：8520-8524,5.DOI:10.3969/j.issn.2095-4344
玻璃酸钠注射膝骨关节炎关节液中一氧化氮及滑膜厚度的变化
Effect of sodium hyaluronate on nitric oxide and synovial thickness in patients with knee osteoarthritis
摘要
Abstract
BACKGROUND:Intra-articular injection of sodium hyaluronate has become a preventive and complementary therapy for knee osteoarthritis that can effectively relieve pain, protect the articular cartilage, and restore the joint function. <br> OBJECTIVE:To observe the effects of sodium hyaluronate on nitric oxide and synovial thickness in patients with knee osteoarthritis. <br> METHODS:Eighty patients with knee osteoarthritis (86 knees) were randomly selected and divided into mild, moderate, severe groups. Intra-articular injection of 25 mg sodium hyaluronate was done once a week for 5 consecutive weeks. At 4 and 12 weeks after treatment, al the patients were subjected to clinical scoring according to the Japanese Knee Osteoarthritis Measure. Thirty-seven patients (40 knees) who could make joint fluid and complete ultrasonic measurement was taken as a complete monitoring group that was also divided into three groups of mild, moderate, and severe. Levels of nitric oxide and synovial thickness were measured before and at 4 weeks after treatment. <br> RESULTS AND CONCLUSION:At 4 weeks after treatment, the effective rates of mild, moderate and severe groups were 93%, 77% and 47 %, respectively, and the total effective rate was 79%. At 12 weeks after treatment, the effective rates of mild, moderate and severe groups were 95%, 84% and 33 %, respectively, and the total effective rate was 80%. In the complete monitoring group, the level of nitric oxide was reduced significantly in mild, moderate and severe patients at 4 weeks after treatment compared with before treatment (P < 0.05), but the synovial thickness had no difference in the mild and severe patients, and only moderate patients appeared to have thinner synovial thickness compared with before treatment (P < 0.05). Experimental findings suggest that sodium hyaluronate can reduce the level of nitric oxide and improve clinical efficacy in patients with knee osteoporosis, especialy for mild and moderate knee osteoporosis patients.关键词
生物材料/骨生物材料/骨关节炎/玻璃酸钠/滑膜/一氧化氮Key words
Subject headings：osteoarthritis/synovial membrane/nitric oxide分类
医药卫生引用本文复制引用
邓剑锋,高大新,刘志新,吴迪,宋红,严佳亮,齐曦明,孙凤丽,赵淑玲..玻璃酸钠注射膝骨关节炎关节液中一氧化氮及滑膜厚度的变化[J].中国组织工程研究,2014,(52):8520-8524,5.基金项目
河北省科学技术研究与发展计划项目(132777102D)Funding：the Scientific Research and Development Plan of Hebei Province, No.132777102D （132777102D）
