中国组织工程研究Issue(2)：277-282,6.DOI:10.3969/j.issn.2095-4344.2015.02.022
姜黄素保护关节软骨抑制骨关节炎的作用和机制
Curcumin prevents against osteoarthritis
张锐 1刘世清1
作者信息
- 1. 武汉大学人民医院骨三科，湖北省武汉市 430060
- 折叠
摘要
Abstract
BACKGROUND:Curcumin is proved to possess anti-inflammatory, antioxidant and anti-apoptotic roles. OBJECTIVE: To summarize and discuss the mechanisms and effects of curcumin used for the treatment of osteoarthritis METHODS: PubMed, Embase, Elseveir databases were retrieved for relevant articles published from 1973 to 2014, with the key words of “osteoarthritis, curcumin, chondrocyte, articular cartilage” in English. After the quality of the included studies was evaluated, valid data were extracted and analyzed. RESULTS AND CONCLUSION:Curcumin prevents the occurrence and development osteoarthritis by inhibiting oxidative enzyme and scavenging free radicals. Curcumin increases production of colagen type 2 through suppressing the reduction of cartilage matrix by matrix metaloproteinases. Anti-inflammatory reaction of curcumin can be achieved by inhibiting cytosolic phospholipase A2, cyclooxygenase-2, and 5-lipoxygenase. Curcumin inhibits interleukin-1β-induced apoptosis of chondrocytes and mitochondrial sweling. Results from clinical trials suggest that curcumin or its derivatives can reduce joint pain and improve the function of knee joints in patients with osteoarthritis. High-concentration curcuminin vitro have been demonstrated toxic effects.关键词
组织构建/骨组织工程/姜黄素/骨关节炎/软骨细胞/关节软骨Key words
Osteoarthritis/Curcumin/Chondrocytes分类
医药卫生引用本文复制引用
张锐,刘世清..姜黄素保护关节软骨抑制骨关节炎的作用和机制[J].中国组织工程研究,2015,(2):277-282,6.
