中国组织工程研究Issue(3)：440-444,5.DOI:10.3969/j.issn.2095-4344
双螺杆挤压人参干预大鼠股骨纵向生长及力学性能改变
Effects of twin-screw extrusion ginseng on the longitudinal growth and biomechanics properties of the femur in rats
摘要
Abstract
BACKGROUND:The twin-screw extrusion technology can alter the chemical composition of ginseng and then produce a new type of ginseng products. <br> OBJECTIVE:To investigate the effect of a new ginseng product, twin-screw extrusion ginseng, on the growth and biomechanics properties of the bone in rats and to discuss the possible biochemistry mechanism. <br> METHODS: Thirty Sprague-Dawley rats were randomly divided into control group, low-, middle-, and high-dose twin-screw extrusion ginseng groups, eight rats in each group. These rats were subjected to intragastric administration of ginseng suspension (0.75, 1.5, 3 g/kg) and distiled water for 3 weeks. After colecting the blood of heart, the femurs were taken to measure the length. Though the three-point bending test, the biomechanical properties such as the maximum bending stress, flexural modulus, bending energy of the femurs were measured. The concentration of osteocalcin and osteogenic growth peptide were tested. <br> RESULTS AND CONCLUSION:The bone length and concentration of osteocalcin and osteogenic growth peptide of rats in the middle-dose twin-screw extrusion ginseng group were significantly higher than those in the control group (P < 0.05). Meanwhile, the biomechanics properties of the bone in the middle-dose twin-screw extrusion ginseng group were also better than those in the control group (P < 0.05). Experimental results show that the twin-screw extrusion ginseng can promote the growth and biomechanics properties of the bone in rats, which may be relevant to the regulation of osteocalcin and osteognic growth peptide.关键词
生物材料/骨生物材料/双螺杆挤压/人参/骨长度/骨钙素/成骨生长肽/生物力学Key words
Funding:the Transverse Task of Yanbian University/No. 2013300-413080001分类
医药卫生引用本文复制引用
卢焕俊,许青松,李范洙,李成福,金元哲..双螺杆挤压人参干预大鼠股骨纵向生长及力学性能改变[J].中国组织工程研究,2015,(3):440-444,5.基金项目
延边大学校横向课题(2013300-413080001) （2013300-413080001）
