中国组织工程研究Issue(6)：934-939,6.DOI:10.3969/j.issn.2095-4344
HLA匹配角膜缘干细胞联合羊膜移植修复翼状胬肉
Co-transplantation of HLA-matched limbal stem cells and amniotic membrane for treatment of pterygium
杨洁 1张金莎 1樱峰1
作者信息
- 1. 新疆医科大学第二附属医院，新疆维吾尔自治区乌鲁木齐市 830063
- 折叠
摘要
Abstract
BACKGROUND:Co-transplantation of HLA-matched limbal stem cels and amniotic membrane is a new concept for the treatment of pterygium, which is characterized as few complications, fast recovery, and low relapse rate. This treatment has been widely used because of reduced rejections. OBJECTIVE:To investigate the therapeutic effect of HLA-matched limbal stem cels and amniotic membrane co-transplantation in the treatment of pterygium. METHODS:Forty-seven patients with pterygium (47 eyes) who underwent the co-transplantation of HLA-matched limbal stem cels and amniotic membrane from March 1, 2013 to April 30, 2014 were enroled as test group. Another 40 patients with pterygium (47 eyes) who received traditional surgical method acted as control group. Therapeutic effectiveness and relapse were compared between the two groups. RESULTS AND CONCLUSION: The 47 cases in the test group were successfuly treated with no complications and rejections, and only one case suffered from incision infection but discharged from hospital after symptomatic treatment. After treatment, pterygium relapsed in 2 of 47 eyes in the test group and 15 of 47 eyes in the control group, and the relapse rates were 4.3% and 31.9%, respectively. Results from this study show that the co-transplantation of HLA-matched limbal stem cels and amniotic membrane for treatment of pterygium has fewer complications and lower relapse rate, which is an effective method for the treatment of pterygium.关键词
干细胞/移植/角膜缘干细胞/HLA相合移植/羊膜移植/翼状胬肉Key words
Subject headings:Pterygium/Amnion/Limbus Corneae/Stem Cels分类
医药卫生引用本文复制引用
杨洁,张金莎,樱峰..HLA匹配角膜缘干细胞联合羊膜移植修复翼状胬肉[J].中国组织工程研究,2015,(6):934-939,6.
